node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B3GALT5 | LCA5L | ENSP00000381699 | ENSP00000351008 | Beta-1,3-galactosyltransferase 5; Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor; Belongs to the glycosyltransferase 31 family. | Lebercilin-like protein; Lebercilin LCA5 like. | 0.537 |
B3GALT5 | MTMR9 | ENSP00000381699 | ENSP00000221086 | Beta-1,3-galactosyltransferase 5; Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor; Belongs to the glycosyltransferase 31 family. | Myotubularin-related protein 9; Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5- bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols. Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3- phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the late stages of ma [...] | 0.426 |
B3GALT5 | PSMG1 | ENSP00000381699 | ENSP00000329915 | Beta-1,3-galactosyltransferase 5; Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor; Belongs to the glycosyltransferase 31 family. | Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. | 0.506 |
B3GALT5 | XKR6 | ENSP00000381699 | ENSP00000416707 | Beta-1,3-galactosyltransferase 5; Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor; Belongs to the glycosyltransferase 31 family. | XK-related protein 6; XK related 6; Belongs to the XK family. | 0.418 |
DNAH12 | LCA5L | ENSP00000312554 | ENSP00000351008 | Dynein heavy chain 12, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). | Lebercilin-like protein; Lebercilin LCA5 like. | 0.537 |
EFHB | LCA5L | ENSP00000295824 | ENSP00000351008 | EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus. | Lebercilin-like protein; Lebercilin LCA5 like. | 0.541 |
EFHB | WDR90 | ENSP00000295824 | ENSP00000293879 | EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus. | WD repeat-containing protein 90; Required for efficient primary cilium formation. | 0.944 |
KRTAP21-2 | LCA5L | ENSP00000334287 | ENSP00000351008 | Keratin-associated protein 21-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | Lebercilin-like protein; Lebercilin LCA5 like. | 0.585 |
LCA5L | B3GALT5 | ENSP00000351008 | ENSP00000381699 | Lebercilin-like protein; Lebercilin LCA5 like. | Beta-1,3-galactosyltransferase 5; Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor; Belongs to the glycosyltransferase 31 family. | 0.537 |
LCA5L | DNAH12 | ENSP00000351008 | ENSP00000312554 | Lebercilin-like protein; Lebercilin LCA5 like. | Dynein heavy chain 12, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). | 0.537 |
LCA5L | EFHB | ENSP00000351008 | ENSP00000295824 | Lebercilin-like protein; Lebercilin LCA5 like. | EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus. | 0.541 |
LCA5L | KRTAP21-2 | ENSP00000351008 | ENSP00000334287 | Lebercilin-like protein; Lebercilin LCA5 like. | Keratin-associated protein 21-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | 0.585 |
LCA5L | MTMR9 | ENSP00000351008 | ENSP00000221086 | Lebercilin-like protein; Lebercilin LCA5 like. | Myotubularin-related protein 9; Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5- bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols. Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3- phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the late stages of ma [...] | 0.541 |
LCA5L | PSMG1 | ENSP00000351008 | ENSP00000329915 | Lebercilin-like protein; Lebercilin LCA5 like. | Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. | 0.697 |
LCA5L | SH3BGR | ENSP00000351008 | ENSP00000332513 | Lebercilin-like protein; Lebercilin LCA5 like. | SH3 domain-binding glutamic acid-rich protein; SH3 domain binding glutamate rich protein; Belongs to the SH3BGR family. | 0.658 |
LCA5L | SH3BGRL | ENSP00000351008 | ENSP00000362308 | Lebercilin-like protein; Lebercilin LCA5 like. | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. | 0.568 |
LCA5L | WDR90 | ENSP00000351008 | ENSP00000293879 | Lebercilin-like protein; Lebercilin LCA5 like. | WD repeat-containing protein 90; Required for efficient primary cilium formation. | 0.577 |
LCA5L | XKR6 | ENSP00000351008 | ENSP00000416707 | Lebercilin-like protein; Lebercilin LCA5 like. | XK-related protein 6; XK related 6; Belongs to the XK family. | 0.539 |
MTMR9 | B3GALT5 | ENSP00000221086 | ENSP00000381699 | Myotubularin-related protein 9; Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5- bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols. Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3- phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the late stages of ma [...] | Beta-1,3-galactosyltransferase 5; Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor; Belongs to the glycosyltransferase 31 family. | 0.426 |
MTMR9 | LCA5L | ENSP00000221086 | ENSP00000351008 | Myotubularin-related protein 9; Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5- bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols. Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3- phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the late stages of ma [...] | Lebercilin-like protein; Lebercilin LCA5 like. | 0.541 |