node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GET3 | SCGB1D4 | ENSP00000466379 | ENSP00000351395 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Secretoglobin family 1D member 4; Seems to be involved in the regulation of chemotactic cell migration and invasion; Belongs to the secretoglobin family. Lipophilin subfamily. | 0.485 |
IGF1 | INS | ENSP00000376637 | ENSP00000380432 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.999 |
IGF1 | SCGB1D4 | ENSP00000376637 | ENSP00000351395 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | Secretoglobin family 1D member 4; Seems to be involved in the regulation of chemotactic cell migration and invasion; Belongs to the secretoglobin family. Lipophilin subfamily. | 0.526 |
IGF1 | TLE7 | ENSP00000376637 | ENSP00000492311 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | Transducin-like enhancer protein 7; TLE family member 7; Belongs to the WD repeat Groucho/TLE family. | 0.591 |
INS | IGF1 | ENSP00000380432 | ENSP00000376637 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.999 |
INS | SCGB1D4 | ENSP00000380432 | ENSP00000351395 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Secretoglobin family 1D member 4; Seems to be involved in the regulation of chemotactic cell migration and invasion; Belongs to the secretoglobin family. Lipophilin subfamily. | 0.477 |
INS | TLE7 | ENSP00000380432 | ENSP00000492311 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Transducin-like enhancer protein 7; TLE family member 7; Belongs to the WD repeat Groucho/TLE family. | 0.553 |
METTL27 | SCGB1D4 | ENSP00000297873 | ENSP00000351395 | Methyltransferase-like protein 27; Methyltransferase like 27. | Secretoglobin family 1D member 4; Seems to be involved in the regulation of chemotactic cell migration and invasion; Belongs to the secretoglobin family. Lipophilin subfamily. | 0.492 |
PPP4R3A | PPP4R3B | ENSP00000450864 | ENSP00000483228 | Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. Belongs to the SMEK family. | Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers; Belongs to the SMEK family. | 0.987 |
PPP4R3A | PPP4R3C | ENSP00000450864 | ENSP00000489770 | Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. Belongs to the SMEK family. | Protein phosphatase 4 regulatory subunit 3C. | 0.907 |
PPP4R3A | SCGB1D4 | ENSP00000450864 | ENSP00000351395 | Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. Belongs to the SMEK family. | Secretoglobin family 1D member 4; Seems to be involved in the regulation of chemotactic cell migration and invasion; Belongs to the secretoglobin family. Lipophilin subfamily. | 0.479 |
PPP4R3B | PPP4R3A | ENSP00000483228 | ENSP00000450864 | Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers; Belongs to the SMEK family. | Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. Belongs to the SMEK family. | 0.987 |
PPP4R3B | PPP4R3C | ENSP00000483228 | ENSP00000489770 | Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers; Belongs to the SMEK family. | Protein phosphatase 4 regulatory subunit 3C. | 0.903 |
PPP4R3B | SCGB1D4 | ENSP00000483228 | ENSP00000351395 | Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers; Belongs to the SMEK family. | Secretoglobin family 1D member 4; Seems to be involved in the regulation of chemotactic cell migration and invasion; Belongs to the secretoglobin family. Lipophilin subfamily. | 0.447 |
PPP4R3C | PPP4R3A | ENSP00000489770 | ENSP00000450864 | Protein phosphatase 4 regulatory subunit 3C. | Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. Belongs to the SMEK family. | 0.907 |
PPP4R3C | PPP4R3B | ENSP00000489770 | ENSP00000483228 | Protein phosphatase 4 regulatory subunit 3C. | Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers; Belongs to the SMEK family. | 0.903 |
PPP4R3C | SCGB1D4 | ENSP00000489770 | ENSP00000351395 | Protein phosphatase 4 regulatory subunit 3C. | Secretoglobin family 1D member 4; Seems to be involved in the regulation of chemotactic cell migration and invasion; Belongs to the secretoglobin family. Lipophilin subfamily. | 0.570 |
SCGB1D4 | GET3 | ENSP00000351395 | ENSP00000466379 | Secretoglobin family 1D member 4; Seems to be involved in the regulation of chemotactic cell migration and invasion; Belongs to the secretoglobin family. Lipophilin subfamily. | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | 0.485 |
SCGB1D4 | IGF1 | ENSP00000351395 | ENSP00000376637 | Secretoglobin family 1D member 4; Seems to be involved in the regulation of chemotactic cell migration and invasion; Belongs to the secretoglobin family. Lipophilin subfamily. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.526 |
SCGB1D4 | INS | ENSP00000351395 | ENSP00000380432 | Secretoglobin family 1D member 4; Seems to be involved in the regulation of chemotactic cell migration and invasion; Belongs to the secretoglobin family. Lipophilin subfamily. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.477 |