node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADO | FAM76B | ENSP00000362888 | ENSP00000351631 | 2-aminoethanethiol dioxygenase. | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | 0.574 |
ARL2BP | FAM76B | ENSP00000219204 | ENSP00000351631 | ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | 0.536 |
CEP57 | FAM76B | ENSP00000317902 | ENSP00000351631 | Centrosomal protein of 57 kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1. | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | 0.545 |
DYRK1A | FAM76B | ENSP00000340373 | ENSP00000351631 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in tu [...] | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | 0.404 |
DYRK1A | PDXK | ENSP00000340373 | ENSP00000291565 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in tu [...] | Pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6; Belongs to the pyridoxine kinase family. | 0.503 |
DYRK1B | FAM76B | ENSP00000469863 | ENSP00000351631 | Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | 0.421 |
FAM76B | ADO | ENSP00000351631 | ENSP00000362888 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | 2-aminoethanethiol dioxygenase. | 0.574 |
FAM76B | ARL2BP | ENSP00000351631 | ENSP00000219204 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. | 0.536 |
FAM76B | CEP57 | ENSP00000351631 | ENSP00000317902 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | Centrosomal protein of 57 kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1. | 0.545 |
FAM76B | DYRK1A | ENSP00000351631 | ENSP00000340373 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in tu [...] | 0.404 |
FAM76B | DYRK1B | ENSP00000351631 | ENSP00000469863 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. | 0.421 |
FAM76B | IDI2 | ENSP00000351631 | ENSP00000277517 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | Isopentenyl-diphosphate delta-isomerase 2; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | 0.433 |
FAM76B | KRTAP10-11 | ENSP00000351631 | ENSP00000334197 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | Keratin-associated protein 10-11; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family. | 0.457 |
FAM76B | PDXK | ENSP00000351631 | ENSP00000291565 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | Pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6; Belongs to the pyridoxine kinase family. | 0.651 |
FAM76B | PPP1R8 | ENSP00000351631 | ENSP00000311677 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | Nuclear inhibitor of protein phosphatase 1; Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre- mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. | 0.429 |
FAM76B | RSRC2 | ENSP00000351631 | ENSP00000330188 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | Arginine and serine rich coiled-coil 2; Belongs to the RSRC2 family. | 0.425 |
IDI2 | FAM76B | ENSP00000277517 | ENSP00000351631 | Isopentenyl-diphosphate delta-isomerase 2; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | 0.433 |
KRTAP10-11 | FAM76B | ENSP00000334197 | ENSP00000351631 | Keratin-associated protein 10-11; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family. | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | 0.457 |
PDXK | DYRK1A | ENSP00000291565 | ENSP00000340373 | Pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6; Belongs to the pyridoxine kinase family. | Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in tu [...] | 0.503 |
PDXK | FAM76B | ENSP00000291565 | ENSP00000351631 | Pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6; Belongs to the pyridoxine kinase family. | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family. | 0.651 |