| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BPIFA1 | FAM3D | ENSP00000346251 | ENSP00000351632 | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | Protein FAM3D; FAM3 metabolism regulating signaling molecule D; Belongs to the FAM3 family. | 0.460 |
| BPIFA1 | ZG16B | ENSP00000346251 | ENSP00000371715 | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | Zymogen granule protein 16B; Belongs to the jacalin lectin family. | 0.493 |
| FAM3D | BPIFA1 | ENSP00000351632 | ENSP00000346251 | Protein FAM3D; FAM3 metabolism regulating signaling molecule D; Belongs to the FAM3 family. | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | 0.460 |
| FAM3D | GUF1 | ENSP00000351632 | ENSP00000281543 | Protein FAM3D; FAM3 metabolism regulating signaling molecule D; Belongs to the FAM3 family. | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily. | 0.570 |
| FAM3D | PIGR | ENSP00000351632 | ENSP00000348888 | Protein FAM3D; FAM3 metabolism regulating signaling molecule D; Belongs to the FAM3 family. | Polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. | 0.402 |
| FAM3D | PKD2 | ENSP00000351632 | ENSP00000237596 | Protein FAM3D; FAM3 metabolism regulating signaling molecule D; Belongs to the FAM3 family. | Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel. Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum. Together with TRPV4, forms mech [...] | 0.778 |
| FAM3D | RAB11FIP1 | ENSP00000351632 | ENSP00000331342 | Protein FAM3D; FAM3 metabolism regulating signaling molecule D; Belongs to the FAM3 family. | Rab11 family-interacting protein 1; A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. | 0.408 |
| FAM3D | RARRES1 | ENSP00000351632 | ENSP00000237696 | Protein FAM3D; FAM3 metabolism regulating signaling molecule D; Belongs to the FAM3 family. | Retinoic acid receptor responder protein 1; Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle. | 0.447 |
| FAM3D | ZG16B | ENSP00000351632 | ENSP00000371715 | Protein FAM3D; FAM3 metabolism regulating signaling molecule D; Belongs to the FAM3 family. | Zymogen granule protein 16B; Belongs to the jacalin lectin family. | 0.423 |
| GUF1 | FAM3D | ENSP00000281543 | ENSP00000351632 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily. | Protein FAM3D; FAM3 metabolism regulating signaling molecule D; Belongs to the FAM3 family. | 0.570 |
| PIGR | FAM3D | ENSP00000348888 | ENSP00000351632 | Polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. | Protein FAM3D; FAM3 metabolism regulating signaling molecule D; Belongs to the FAM3 family. | 0.402 |
| PKD2 | FAM3D | ENSP00000237596 | ENSP00000351632 | Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel. Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum. Together with TRPV4, forms mech [...] | Protein FAM3D; FAM3 metabolism regulating signaling molecule D; Belongs to the FAM3 family. | 0.778 |
| RAB11FIP1 | FAM3D | ENSP00000331342 | ENSP00000351632 | Rab11 family-interacting protein 1; A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. | Protein FAM3D; FAM3 metabolism regulating signaling molecule D; Belongs to the FAM3 family. | 0.408 |
| RARRES1 | FAM3D | ENSP00000237696 | ENSP00000351632 | Retinoic acid receptor responder protein 1; Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle. | Protein FAM3D; FAM3 metabolism regulating signaling molecule D; Belongs to the FAM3 family. | 0.447 |
| ZG16B | BPIFA1 | ENSP00000371715 | ENSP00000346251 | Zymogen granule protein 16B; Belongs to the jacalin lectin family. | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | 0.493 |
| ZG16B | FAM3D | ENSP00000371715 | ENSP00000351632 | Zymogen granule protein 16B; Belongs to the jacalin lectin family. | Protein FAM3D; FAM3 metabolism regulating signaling molecule D; Belongs to the FAM3 family. | 0.423 |
