node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APRT | GMPS | ENSP00000367615 | ENSP00000419851 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | 0.995 |
APRT | MANEA | ENSP00000367615 | ENSP00000351669 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | 0.526 |
APRT | RRM1 | ENSP00000367615 | ENSP00000300738 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.417 |
CNDP1 | MANEA | ENSP00000351682 | ENSP00000351669 | Carnosine dipeptidase 1; Belongs to the peptidase M20A family. | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | 0.510 |
COL18A1 | MANEA | ENSP00000352798 | ENSP00000351669 | Collagen alpha-1(XVIII) chain; Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner [...] | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | 0.471 |
GMPS | APRT | ENSP00000419851 | ENSP00000367615 | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.995 |
GMPS | MANEA | ENSP00000419851 | ENSP00000351669 | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | 0.580 |
GMPS | RRM1 | ENSP00000419851 | ENSP00000300738 | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.748 |
GPR63 | MANEA | ENSP00000229955 | ENSP00000351669 | Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function. | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | 0.475 |
MAN1B1 | MANEA | ENSP00000360645 | ENSP00000351669 | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2); Belongs to the glycosyl hydrolase 47 family. | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | 0.935 |
MAN1B1 | MOGS | ENSP00000360645 | ENSP00000410992 | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2); Belongs to the glycosyl hydrolase 47 family. | Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner; Belongs to the glycosyl hydrolase 63 family. | 0.852 |
MANEA | APRT | ENSP00000351669 | ENSP00000367615 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.526 |
MANEA | CNDP1 | ENSP00000351669 | ENSP00000351682 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | Carnosine dipeptidase 1; Belongs to the peptidase M20A family. | 0.510 |
MANEA | COL18A1 | ENSP00000351669 | ENSP00000352798 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | Collagen alpha-1(XVIII) chain; Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner [...] | 0.471 |
MANEA | GMPS | ENSP00000351669 | ENSP00000419851 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. | 0.580 |
MANEA | GPR63 | ENSP00000351669 | ENSP00000229955 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function. | 0.475 |
MANEA | MAN1B1 | ENSP00000351669 | ENSP00000360645 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2); Belongs to the glycosyl hydrolase 47 family. | 0.935 |
MANEA | MGAT5B | ENSP00000351669 | ENSP00000391227 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B; Glycosyltransferase that acts on alpha-linked mannose of N- glycans and O-mannosyl glycans. Catalyzes the transfer of N- acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6- linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migrat [...] | 0.524 |
MANEA | MOGS | ENSP00000351669 | ENSP00000410992 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner; Belongs to the glycosyl hydrolase 63 family. | 0.505 |
MANEA | POLR2F | ENSP00000351669 | ENSP00000385725 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha. | DNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of th [...] | 0.482 |