node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MUCL3 | SFTA2 | ENSP00000417182 | ENSP00000351989 | Mucin-like protein 3; May modulate NF-kappaB signaling and play a role in cell growth. | Surfactant-associated protein 2; Putative surfactant protein. | 0.544 |
MUCL3 | VARS1 | ENSP00000417182 | ENSP00000364815 | Mucin-like protein 3; May modulate NF-kappaB signaling and play a role in cell growth. | Valine--tRNA ligase; valyl-tRNA synthetase 1; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.449 |
MUCL3 | VARS2 | ENSP00000417182 | ENSP00000441000 | Mucin-like protein 3; May modulate NF-kappaB signaling and play a role in cell growth. | Valine--tRNA ligase, mitochondrial; valyl-tRNA synthetase 2, mitochondrial. | 0.419 |
SCGB3A2 | SFTA2 | ENSP00000296694 | ENSP00000351989 | Secretoglobin family 3A member 2; Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production [...] | Surfactant-associated protein 2; Putative surfactant protein. | 0.474 |
SCGB3A2 | SFTPA1 | ENSP00000296694 | ENSP00000397082 | Secretoglobin family 3A member 2; Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production [...] | Pulmonary surfactant-associated protein A1; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity). | 0.903 |
SCGB3A2 | SFTPA2 | ENSP00000296694 | ENSP00000361400 | Secretoglobin family 3A member 2; Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production [...] | Surfactant protein A2. | 0.593 |
SCGB3A2 | SFTPB | ENSP00000296694 | ENSP00000499683 | Secretoglobin family 3A member 2; Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production [...] | Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. | 0.775 |
SCGB3A2 | SFTPC | ENSP00000296694 | ENSP00000316152 | Secretoglobin family 3A member 2; Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production [...] | Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. | 0.850 |
SCGB3A2 | SFTPD | ENSP00000296694 | ENSP00000361366 | Secretoglobin family 3A member 2; Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production [...] | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties. | 0.648 |
SFTA2 | MUCL3 | ENSP00000351989 | ENSP00000417182 | Surfactant-associated protein 2; Putative surfactant protein. | Mucin-like protein 3; May modulate NF-kappaB signaling and play a role in cell growth. | 0.544 |
SFTA2 | SCGB3A2 | ENSP00000351989 | ENSP00000296694 | Surfactant-associated protein 2; Putative surfactant protein. | Secretoglobin family 3A member 2; Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium (By similarity). Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production [...] | 0.474 |
SFTA2 | SFTA3 | ENSP00000351989 | ENSP00000428331 | Surfactant-associated protein 2; Putative surfactant protein. | Surfactant-associated protein 3; Putative surfactant protein. May be involved in wound healing and in the reduction of the surface tension at the ocular surface. | 0.649 |
SFTA2 | SFTPA1 | ENSP00000351989 | ENSP00000397082 | Surfactant-associated protein 2; Putative surfactant protein. | Pulmonary surfactant-associated protein A1; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity). | 0.632 |
SFTA2 | SFTPA2 | ENSP00000351989 | ENSP00000361400 | Surfactant-associated protein 2; Putative surfactant protein. | Surfactant protein A2. | 0.515 |
SFTA2 | SFTPB | ENSP00000351989 | ENSP00000499683 | Surfactant-associated protein 2; Putative surfactant protein. | Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. | 0.453 |
SFTA2 | SFTPC | ENSP00000351989 | ENSP00000316152 | Surfactant-associated protein 2; Putative surfactant protein. | Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. | 0.505 |
SFTA2 | SFTPD | ENSP00000351989 | ENSP00000361366 | Surfactant-associated protein 2; Putative surfactant protein. | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties. | 0.447 |
SFTA2 | VARS1 | ENSP00000351989 | ENSP00000364815 | Surfactant-associated protein 2; Putative surfactant protein. | Valine--tRNA ligase; valyl-tRNA synthetase 1; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.447 |
SFTA2 | VARS2 | ENSP00000351989 | ENSP00000441000 | Surfactant-associated protein 2; Putative surfactant protein. | Valine--tRNA ligase, mitochondrial; valyl-tRNA synthetase 2, mitochondrial. | 0.418 |
SFTA3 | SFTA2 | ENSP00000428331 | ENSP00000351989 | Surfactant-associated protein 3; Putative surfactant protein. May be involved in wound healing and in the reduction of the surface tension at the ocular surface. | Surfactant-associated protein 2; Putative surfactant protein. | 0.649 |