VSIG10 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD13D	LRRC73	ENSP00000427130	ENSP00000361518	Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73.	0.621
ANKRD13D	TEPSIN	ENSP00000427130	ENSP00000490393	Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.	0.620
ANKRD13D	VSIG10	ENSP00000427130	ENSP00000352172	Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	V-set and immunoglobulin domain containing 10.	0.530
CCDC36	VSIG10	ENSP00000391788	ENSP00000352172	Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.	V-set and immunoglobulin domain containing 10.	0.424
LRRC73	ANKRD13D	ENSP00000361518	ENSP00000427130	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73.	Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	0.621
LRRC73	TEPSIN	ENSP00000361518	ENSP00000490393	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73.	AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.	0.595
LRRC73	VSIG10	ENSP00000361518	ENSP00000352172	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73.	V-set and immunoglobulin domain containing 10.	0.609
LYPLAL1	TTC17	ENSP00000355895	ENSP00000039989	Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site. Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	Tetratricopeptide repeat protein 17; Plays a role in primary ciliogenesis by modulating actin polymerization.	0.440
LYPLAL1	VSIG10	ENSP00000355895	ENSP00000352172	Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site. Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	V-set and immunoglobulin domain containing 10.	0.443
OR2I1P	VSIG10	ENSP00000493715	ENSP00000352172	Putative olfactory receptor 2I1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	V-set and immunoglobulin domain containing 10.	0.492
POLR3D	VSIG10	ENSP00000380904	ENSP00000352172	DNA-directed RNA polymerase III subunit RPC4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...]	V-set and immunoglobulin domain containing 10.	0.454
TEPSIN	ANKRD13D	ENSP00000490393	ENSP00000427130	AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.	Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	0.620
TEPSIN	LRRC73	ENSP00000490393	ENSP00000361518	AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73.	0.595
TEPSIN	VSIG10	ENSP00000490393	ENSP00000352172	AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.	V-set and immunoglobulin domain containing 10.	0.523
TTC17	LYPLAL1	ENSP00000039989	ENSP00000355895	Tetratricopeptide repeat protein 17; Plays a role in primary ciliogenesis by modulating actin polymerization.	Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site. Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	0.440
TTC17	VSIG10	ENSP00000039989	ENSP00000352172	Tetratricopeptide repeat protein 17; Plays a role in primary ciliogenesis by modulating actin polymerization.	V-set and immunoglobulin domain containing 10.	0.496
VSIG10	ANKRD13D	ENSP00000352172	ENSP00000427130	V-set and immunoglobulin domain containing 10.	Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.	0.530
VSIG10	CCDC36	ENSP00000352172	ENSP00000391788	V-set and immunoglobulin domain containing 10.	Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.	0.424
VSIG10	LRRC73	ENSP00000352172	ENSP00000361518	V-set and immunoglobulin domain containing 10.	Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73.	0.609
VSIG10	LYPLAL1	ENSP00000352172	ENSP00000355895	V-set and immunoglobulin domain containing 10.	Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site. Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.	0.443