TMEM139 protein (human) - STRING interaction network

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
INAVA	TMEM139	ENSP00000392105	ENSP00000352284	Innate immunity activator protein; Expressed in peripheral macrophages and intestinal myeloid- derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulate [...]	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	0.423
ITPKC	TMEM139	ENSP00000263370	ENSP00000352284	Inositol-trisphosphate 3-kinase C; Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate; Belongs to the inositol phosphokinase (IPK) family.	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	0.453
RPS6KA3	TMEM139	ENSP00000368884	ENSP00000352284	Ribosomal protein S6 kinase alpha-3; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro- apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subseq [...]	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	0.776
THTPA	TMEM139	ENSP00000288014	ENSP00000352284	Thiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP). Belongs to the ThTPase family.	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	0.524
TMEM139	INAVA	ENSP00000352284	ENSP00000392105	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	Innate immunity activator protein; Expressed in peripheral macrophages and intestinal myeloid- derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulate [...]	0.423
TMEM139	ITPKC	ENSP00000352284	ENSP00000263370	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	Inositol-trisphosphate 3-kinase C; Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate; Belongs to the inositol phosphokinase (IPK) family.	0.453
TMEM139	RPS6KA3	ENSP00000352284	ENSP00000368884	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	Ribosomal protein S6 kinase alpha-3; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro- apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subseq [...]	0.776
TMEM139	THTPA	ENSP00000352284	ENSP00000288014	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	Thiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP). Belongs to the ThTPase family.	0.524
TMEM139	TMEM14A	ENSP00000352284	ENSP00000211314	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family.	0.490
TMEM139	TMEM158	ENSP00000352284	ENSP00000422431	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	Transmembrane protein 158; Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.	0.459
TMEM139	TMEM183A	ENSP00000352284	ENSP00000356211	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	Transmembrane protein 183A.	0.459
TMEM139	TMEM25	ENSP00000352284	ENSP00000431548	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability.	0.605
TMEM139	TMEM44	ENSP00000352284	ENSP00000376227	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	Transmembrane protein 44.	0.467
TMEM139	TRIM68	ENSP00000352284	ENSP00000300747	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	E3 ubiquitin-protein ligase TRIM68; Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.	0.710
TMEM14A	TMEM139	ENSP00000211314	ENSP00000352284	Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family.	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	0.490
TMEM14A	TMEM158	ENSP00000211314	ENSP00000422431	Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family.	Transmembrane protein 158; Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.	0.596
TMEM14A	TMEM25	ENSP00000211314	ENSP00000431548	Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family.	Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability.	0.631
TMEM158	TMEM139	ENSP00000422431	ENSP00000352284	Transmembrane protein 158; Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.	Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.	0.459
TMEM158	TMEM14A	ENSP00000422431	ENSP00000211314	Transmembrane protein 158; Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.	Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family.	0.596
TMEM158	TMEM25	ENSP00000422431	ENSP00000431548	Transmembrane protein 158; Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.	Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability.	0.597