TMC3 protein (human) - STRING interaction network

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TMC3

Transmembrane channel-like protein 3; Probable ion channel. (1100 aa)

Predicted Functional Partners:

LHFPL5

0.475

UNC5CL

0.469

OR6K6

0.466

OR4X1

0.441

ZNF343

0.434

PCDH15

0.429

ANKDD1B

0.425

STT3A

0.423

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKDD1B	OR4X1	ENSP00000471417	ENSP00000321506	Ankyrin repeat and death domain containing 1B.	Olfactory receptor 4X1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.497
ANKDD1B	TMC3	ENSP00000471417	ENSP00000352413	Ankyrin repeat and death domain containing 1B.	Transmembrane channel-like protein 3; Probable ion channel.	0.425
LHFPL5	PCDH15	ENSP00000498322	ENSP00000363068	LHFPL tetraspan subfamily member 5 protein; In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity).	Protocadherin-15; Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.	0.979
LHFPL5	STT3A	ENSP00000498322	ENSP00000376472	LHFPL tetraspan subfamily member 5 protein; In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity).	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...]	0.402
LHFPL5	TMC3	ENSP00000498322	ENSP00000352413	LHFPL tetraspan subfamily member 5 protein; In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity).	Transmembrane channel-like protein 3; Probable ion channel.	0.475
OR4X1	ANKDD1B	ENSP00000321506	ENSP00000471417	Olfactory receptor 4X1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	Ankyrin repeat and death domain containing 1B.	0.497
OR4X1	TMC3	ENSP00000321506	ENSP00000352413	Olfactory receptor 4X1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	Transmembrane channel-like protein 3; Probable ion channel.	0.441
OR6K6	TMC3	ENSP00000357126	ENSP00000352413	Olfactory receptor 6K6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	Transmembrane channel-like protein 3; Probable ion channel.	0.466
OR6K6	UNC5CL	ENSP00000357126	ENSP00000244565	Olfactory receptor 6K6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF- kappa-B binding to its targets; Belongs to the unc-5 family.	0.500
PCDH15	LHFPL5	ENSP00000363068	ENSP00000498322	Protocadherin-15; Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.	LHFPL tetraspan subfamily member 5 protein; In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity).	0.979
PCDH15	TMC3	ENSP00000363068	ENSP00000352413	Protocadherin-15; Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.	Transmembrane channel-like protein 3; Probable ion channel.	0.429
STT3A	LHFPL5	ENSP00000376472	ENSP00000498322	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...]	LHFPL tetraspan subfamily member 5 protein; In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity).	0.402
STT3A	TMC3	ENSP00000376472	ENSP00000352413	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...]	Transmembrane channel-like protein 3; Probable ion channel.	0.423
TMC3	ANKDD1B	ENSP00000352413	ENSP00000471417	Transmembrane channel-like protein 3; Probable ion channel.	Ankyrin repeat and death domain containing 1B.	0.425
TMC3	LHFPL5	ENSP00000352413	ENSP00000498322	Transmembrane channel-like protein 3; Probable ion channel.	LHFPL tetraspan subfamily member 5 protein; In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity).	0.475
TMC3	OR4X1	ENSP00000352413	ENSP00000321506	Transmembrane channel-like protein 3; Probable ion channel.	Olfactory receptor 4X1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.441
TMC3	OR6K6	ENSP00000352413	ENSP00000357126	Transmembrane channel-like protein 3; Probable ion channel.	Olfactory receptor 6K6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.466
TMC3	PCDH15	ENSP00000352413	ENSP00000363068	Transmembrane channel-like protein 3; Probable ion channel.	Protocadherin-15; Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.	0.429
TMC3	STT3A	ENSP00000352413	ENSP00000376472	Transmembrane channel-like protein 3; Probable ion channel.	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...]	0.423
TMC3	UNC5CL	ENSP00000352413	ENSP00000244565	Transmembrane channel-like protein 3; Probable ion channel.	UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF- kappa-B binding to its targets; Belongs to the unc-5 family.	0.469