node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC37L1 | ECM1 | ENSP00000371278 | ENSP00000358045 | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | Extracellular matrix protein 1; Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. | 0.400 |
CDC37L1 | FAM3C | ENSP00000371278 | ENSP00000353025 | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | 0.463 |
CPED1 | FAM3C | ENSP00000309772 | ENSP00000353025 | Cadherin like and PC-esterase domain containing 1. | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | 0.657 |
CPED1 | WNT16 | ENSP00000309772 | ENSP00000222462 | Cadherin like and PC-esterase domain containing 1. | Protein Wnt-16; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). | 0.702 |
CREB3L1 | FAM3C | ENSP00000481956 | ENSP00000353025 | Processed cyclic AMP-responsive element-binding protein 3-like protein 1; Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3'. In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated [...] | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | 0.523 |
CXADR | FAM3C | ENSP00000284878 | ENSP00000353025 | Coxsackievirus and adenovirus receptor; Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downs [...] | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | 0.549 |
ECM1 | CDC37L1 | ENSP00000358045 | ENSP00000371278 | Extracellular matrix protein 1; Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | 0.400 |
ECM1 | FAM3C | ENSP00000358045 | ENSP00000353025 | Extracellular matrix protein 1; Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | 0.471 |
FAM3C | CDC37L1 | ENSP00000353025 | ENSP00000371278 | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. | 0.463 |
FAM3C | CPED1 | ENSP00000353025 | ENSP00000309772 | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | Cadherin like and PC-esterase domain containing 1. | 0.657 |
FAM3C | CREB3L1 | ENSP00000353025 | ENSP00000481956 | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | Processed cyclic AMP-responsive element-binding protein 3-like protein 1; Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3'. In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated [...] | 0.523 |
FAM3C | CXADR | ENSP00000353025 | ENSP00000284878 | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | Coxsackievirus and adenovirus receptor; Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downs [...] | 0.549 |
FAM3C | ECM1 | ENSP00000353025 | ENSP00000358045 | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | Extracellular matrix protein 1; Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. | 0.471 |
FAM3C | HLA-C | ENSP00000353025 | ENSP00000365402 | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | HLA class I histocompatibility antigen, C alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity. In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells. In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary [...] | 0.755 |
FAM3C | LAMP1 | ENSP00000353025 | ENSP00000333298 | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. | 0.812 |
FAM3C | PCBP1 | ENSP00000353025 | ENSP00000305556 | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | Poly(rC)-binding protein 1; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. | 0.530 |
FAM3C | PDCD1 | ENSP00000353025 | ENSP00000335062 | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | Programmed cell death protein 1; Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the pr [...] | 0.734 |
FAM3C | WNT16 | ENSP00000353025 | ENSP00000222462 | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | Protein Wnt-16; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). | 0.513 |
HLA-C | FAM3C | ENSP00000365402 | ENSP00000353025 | HLA class I histocompatibility antigen, C alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity. In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells. In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary [...] | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. | 0.755 |
HLA-C | LAMP1 | ENSP00000365402 | ENSP00000333298 | HLA class I histocompatibility antigen, C alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity. In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells. In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary [...] | Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. | 0.525 |