node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COMMD5 | ZNF517 | ENSP00000394331 | ENSP00000353058 | COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B. | Zinc finger protein 517; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.540 |
CRIPAK | ZNF517 | ENSP00000323978 | ENSP00000353058 | Cysteine-rich PAK1 inhibitor; Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence. | Zinc finger protein 517; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.595 |
CYHR1 | ZNF517 | ENSP00000433769 | ENSP00000353058 | Cysteine and histidine rich 1; Belongs to the CYHR1 family. | Zinc finger protein 517; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.418 |
TRIM28 | ZNF133 | ENSP00000253024 | ENSP00000439427 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | 0.784 |
TRIM28 | ZNF517 | ENSP00000253024 | ENSP00000353058 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 517; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.676 |
TSHZ3 | ZNF385B | ENSP00000240587 | ENSP00000386845 | Teashirt homolog 3; Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway func [...] | Zinc finger protein 385B; May play a role in p53/TP53-mediated apoptosis. | 0.469 |
TSHZ3 | ZNF517 | ENSP00000240587 | ENSP00000353058 | Teashirt homolog 3; Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway func [...] | Zinc finger protein 517; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.452 |
ZNF133 | TRIM28 | ENSP00000439427 | ENSP00000253024 | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.784 |
ZNF133 | ZNF517 | ENSP00000439427 | ENSP00000353058 | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | Zinc finger protein 517; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.469 |
ZNF292 | ZNF385B | ENSP00000358590 | ENSP00000386845 | Zinc finger protein 292; May be involved in transcriptional regulation. | Zinc finger protein 385B; May play a role in p53/TP53-mediated apoptosis. | 0.444 |
ZNF292 | ZNF517 | ENSP00000358590 | ENSP00000353058 | Zinc finger protein 292; May be involved in transcriptional regulation. | Zinc finger protein 517; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.461 |
ZNF385B | TSHZ3 | ENSP00000386845 | ENSP00000240587 | Zinc finger protein 385B; May play a role in p53/TP53-mediated apoptosis. | Teashirt homolog 3; Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway func [...] | 0.469 |
ZNF385B | ZNF292 | ENSP00000386845 | ENSP00000358590 | Zinc finger protein 385B; May play a role in p53/TP53-mediated apoptosis. | Zinc finger protein 292; May be involved in transcriptional regulation. | 0.444 |
ZNF385B | ZNF517 | ENSP00000386845 | ENSP00000353058 | Zinc finger protein 385B; May play a role in p53/TP53-mediated apoptosis. | Zinc finger protein 517; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.511 |
ZNF517 | COMMD5 | ENSP00000353058 | ENSP00000394331 | Zinc finger protein 517; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B. | 0.540 |
ZNF517 | CRIPAK | ENSP00000353058 | ENSP00000323978 | Zinc finger protein 517; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Cysteine-rich PAK1 inhibitor; Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence. | 0.595 |
ZNF517 | CYHR1 | ENSP00000353058 | ENSP00000433769 | Zinc finger protein 517; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Cysteine and histidine rich 1; Belongs to the CYHR1 family. | 0.418 |
ZNF517 | TRIM28 | ENSP00000353058 | ENSP00000253024 | Zinc finger protein 517; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.676 |
ZNF517 | TSHZ3 | ENSP00000353058 | ENSP00000240587 | Zinc finger protein 517; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Teashirt homolog 3; Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway func [...] | 0.452 |
ZNF517 | ZNF133 | ENSP00000353058 | ENSP00000439427 | Zinc finger protein 517; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | 0.469 |