node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTN1 | AHNAK2 | ENSP00000377941 | ENSP00000353114 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Belongs to the alpha-actinin family. | AHNAK nucleoprotein 2. | 0.618 |
ACTN1 | ANXA2 | ENSP00000377941 | ENSP00000346032 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Belongs to the alpha-actinin family. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family. | 0.562 |
ACTN1 | CAV1 | ENSP00000377941 | ENSP00000339191 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Belongs to the alpha-actinin family. | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recrui [...] | 0.641 |
AHNAK | AHNAK2 | ENSP00000367263 | ENSP00000353114 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | AHNAK nucleoprotein 2. | 0.944 |
AHNAK | ANXA2 | ENSP00000367263 | ENSP00000346032 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family. | 0.999 |
AHNAK | DYSF | ENSP00000367263 | ENSP00000386881 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family. | 0.982 |
AHNAK | MYOF | ENSP00000367263 | ENSP00000352208 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Myoferlin; Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). | 0.849 |
AHNAK | S100A10 | ENSP00000367263 | ENSP00000357801 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family. | 0.999 |
AHNAK2 | ACTN1 | ENSP00000353114 | ENSP00000377941 | AHNAK nucleoprotein 2. | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Belongs to the alpha-actinin family. | 0.618 |
AHNAK2 | AHNAK | ENSP00000353114 | ENSP00000367263 | AHNAK nucleoprotein 2. | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | 0.944 |
AHNAK2 | ANXA2 | ENSP00000353114 | ENSP00000346032 | AHNAK nucleoprotein 2. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family. | 0.971 |
AHNAK2 | CACNA1S | ENSP00000353114 | ENSP00000355192 | AHNAK nucleoprotein 2. | Voltage-dependent L-type calcium channel subunit alpha-1S; Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. | 0.563 |
AHNAK2 | CAV1 | ENSP00000353114 | ENSP00000339191 | AHNAK nucleoprotein 2. | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recrui [...] | 0.571 |
AHNAK2 | DYSF | ENSP00000353114 | ENSP00000386881 | AHNAK nucleoprotein 2. | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family. | 0.501 |
AHNAK2 | MUC16 | ENSP00000353114 | ENSP00000381008 | AHNAK nucleoprotein 2. | Mucin-16; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. | 0.493 |
AHNAK2 | MUC17 | ENSP00000353114 | ENSP00000302716 | AHNAK nucleoprotein 2. | Mucin-17; Probably plays a role in maintaining homeostasis on mucosal surfaces. | 0.473 |
AHNAK2 | MYOF | ENSP00000353114 | ENSP00000352208 | AHNAK nucleoprotein 2. | Myoferlin; Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). | 0.536 |
AHNAK2 | S100A10 | ENSP00000353114 | ENSP00000357801 | AHNAK nucleoprotein 2. | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family. | 0.949 |
ANXA2 | ACTN1 | ENSP00000346032 | ENSP00000377941 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family. | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Belongs to the alpha-actinin family. | 0.562 |
ANXA2 | AHNAK | ENSP00000346032 | ENSP00000367263 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 ; Belongs to the annexin family. | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. | 0.999 |