node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM19 | FAM13A | ENSP00000257527 | ENSP00000264344 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | 0.523 |
ADAM19 | GSTCD | ENSP00000257527 | ENSP00000422354 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | 0.584 |
ADAM19 | HHIP | ENSP00000257527 | ENSP00000296575 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family; Belongs to the HHIP family. | 0.418 |
ADAM19 | INTS12 | ENSP00000257527 | ENSP00000415433 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | Integrator complex subunit 12; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | 0.477 |
ADAM19 | PID1 | ENSP00000257527 | ENSP00000283937 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | PTB-containing, cubilin and LRP1-interacting protein; Increases proliferation of preadipocytes without affecting adipocytic differentiation. | 0.420 |
ADAM19 | PPT2 | ENSP00000257527 | ENSP00000354608 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. | 0.418 |
ADAM19 | THSD4 | ENSP00000257527 | ENSP00000347484 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity). | 0.452 |
FAM13A | ADAM19 | ENSP00000264344 | ENSP00000257527 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | 0.523 |
FAM13A | GSTCD | ENSP00000264344 | ENSP00000422354 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | 0.708 |
FAM13A | HHIP | ENSP00000264344 | ENSP00000296575 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family; Belongs to the HHIP family. | 0.854 |
FAM13A | INTS12 | ENSP00000264344 | ENSP00000415433 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Integrator complex subunit 12; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | 0.574 |
FAM13A | NPNT | ENSP00000264344 | ENSP00000389252 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Nephronectin; Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity). | 0.495 |
FAM13A | PID1 | ENSP00000264344 | ENSP00000283937 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | PTB-containing, cubilin and LRP1-interacting protein; Increases proliferation of preadipocytes without affecting adipocytic differentiation. | 0.584 |
FAM13A | PPT2 | ENSP00000264344 | ENSP00000354608 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. | 0.540 |
FAM13A | THSD4 | ENSP00000264344 | ENSP00000347484 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity). | 0.601 |
FAM13A | TNS1 | ENSP00000264344 | ENSP00000171887 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Tensin-1; Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. | 0.447 |
GSTCD | ADAM19 | ENSP00000422354 | ENSP00000257527 | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). | 0.584 |
GSTCD | FAM13A | ENSP00000422354 | ENSP00000264344 | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | 0.708 |
GSTCD | HHIP | ENSP00000422354 | ENSP00000296575 | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family; Belongs to the HHIP family. | 0.632 |
GSTCD | INTS12 | ENSP00000422354 | ENSP00000415433 | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | Integrator complex subunit 12; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | 0.775 |