C15orf39 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C15orf39	CARD8	ENSP00000353854	ENSP00000499211	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.	0.575
C15orf39	CCNJL	ENSP00000353854	ENSP00000377547	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	Cyclin-J-like protein; Cyclin J like.	0.568
C15orf39	CTBP1	ENSP00000353854	ENSP00000290921	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	C-terminal-binding protein 1; Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.774
C15orf39	FAM217A	ENSP00000353854	ENSP00000274673	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	Protein FAM217A; Family with sequence similarity 217 member A; Belongs to the FAM217 family.	0.564
C15orf39	FAM219B	ENSP00000353854	ENSP00000350260	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	Protein FAM219B; Family with sequence similarity 219 member B.	0.571
C15orf39	GOLGA6C	ENSP00000353854	ENSP00000300576	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	Golgin A6 family member C; Belongs to the GOLGA6 family.	0.470
C15orf39	MAD2L1	ENSP00000353854	ENSP00000296509	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.	0.649
C15orf39	MAD2L1BP	ENSP00000353854	ENSP00000410818	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	MAD2L1-binding protein; May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. Belongs to the MAD2L1BP family.	0.813
C15orf39	PRMT2	ENSP00000353854	ENSP00000380759	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	Protein arginine N-methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)- mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation.	0.514
C15orf39	RFPL4B	ENSP00000353854	ENSP00000423391	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	Ret finger protein like 4B.	0.551
CARD8	C15orf39	ENSP00000499211	ENSP00000353854	Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	0.575
CCNJL	C15orf39	ENSP00000377547	ENSP00000353854	Cyclin-J-like protein; Cyclin J like.	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	0.568
CTBP1	C15orf39	ENSP00000290921	ENSP00000353854	C-terminal-binding protein 1; Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	0.774
FAM217A	C15orf39	ENSP00000274673	ENSP00000353854	Protein FAM217A; Family with sequence similarity 217 member A; Belongs to the FAM217 family.	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	0.564
FAM219B	C15orf39	ENSP00000350260	ENSP00000353854	Protein FAM219B; Family with sequence similarity 219 member B.	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	0.571
FAM219B	GOLGA6C	ENSP00000350260	ENSP00000300576	Protein FAM219B; Family with sequence similarity 219 member B.	Golgin A6 family member C; Belongs to the GOLGA6 family.	0.521
GOLGA6C	C15orf39	ENSP00000300576	ENSP00000353854	Golgin A6 family member C; Belongs to the GOLGA6 family.	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	0.470
GOLGA6C	FAM219B	ENSP00000300576	ENSP00000350260	Golgin A6 family member C; Belongs to the GOLGA6 family.	Protein FAM219B; Family with sequence similarity 219 member B.	0.521
MAD2L1	C15orf39	ENSP00000296509	ENSP00000353854	Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.	0.649
MAD2L1	MAD2L1BP	ENSP00000296509	ENSP00000410818	Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.	MAD2L1-binding protein; May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. Belongs to the MAD2L1BP family.	0.999