node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C15orf39 | C19orf47 | ENSP00000353854 | ENSP00000463159 | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | Uncharacterized protein C19orf47; Chromosome 19 open reading frame 47. | 0.451 |
C15orf39 | CTBP1 | ENSP00000353854 | ENSP00000290921 | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | C-terminal-binding protein 1; Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.466 |
C15orf39 | FAM193B | ENSP00000353854 | ENSP00000422131 | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | 0.405 |
C15orf39 | FAM219B | ENSP00000353854 | ENSP00000350260 | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | Protein FAM219B; Family with sequence similarity 219 member B. | 0.581 |
C15orf39 | GPALPP1 | ENSP00000353854 | ENSP00000368447 | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | GPALPP motifs containing 1. | 0.434 |
C15orf39 | PDCD1 | ENSP00000353854 | ENSP00000335062 | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | Programmed cell death protein 1; Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the pr [...] | 0.409 |
C15orf39 | SCAMP5 | ENSP00000353854 | ENSP00000355387 | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | Secretory carrier-associated membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway. | 0.404 |
C15orf39 | TINF2 | ENSP00000353854 | ENSP00000267415 | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | TERF1-interacting nuclear factor 2; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. | 0.413 |
C15orf39 | UBL7 | ENSP00000353854 | ENSP00000457703 | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | Ubiquitin-like protein 7; Ubiquitin like 7. | 0.480 |
C15orf39 | ULK3 | ENSP00000353854 | ENSP00000400312 | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | Serine/threonine-protein kinase ULK3; Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as we [...] | 0.411 |
C19orf47 | C15orf39 | ENSP00000463159 | ENSP00000353854 | Uncharacterized protein C19orf47; Chromosome 19 open reading frame 47. | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | 0.451 |
CTBP1 | C15orf39 | ENSP00000290921 | ENSP00000353854 | C-terminal-binding protein 1; Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | 0.466 |
FAM193B | C15orf39 | ENSP00000422131 | ENSP00000353854 | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family. | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | 0.405 |
FAM219B | C15orf39 | ENSP00000350260 | ENSP00000353854 | Protein FAM219B; Family with sequence similarity 219 member B. | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | 0.581 |
FAM219B | ULK3 | ENSP00000350260 | ENSP00000400312 | Protein FAM219B; Family with sequence similarity 219 member B. | Serine/threonine-protein kinase ULK3; Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as we [...] | 0.569 |
GPALPP1 | C15orf39 | ENSP00000368447 | ENSP00000353854 | GPALPP motifs containing 1. | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | 0.434 |
PDCD1 | C15orf39 | ENSP00000335062 | ENSP00000353854 | Programmed cell death protein 1; Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the pr [...] | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | 0.409 |
SCAMP5 | C15orf39 | ENSP00000355387 | ENSP00000353854 | Secretory carrier-associated membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway. | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | 0.404 |
TINF2 | C15orf39 | ENSP00000267415 | ENSP00000353854 | TERF1-interacting nuclear factor 2; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | 0.413 |
UBL7 | C15orf39 | ENSP00000457703 | ENSP00000353854 | Ubiquitin-like protein 7; Ubiquitin like 7. | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39. | 0.480 |