| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1R | C1S | ENSP00000444271 | ENSP00000385035 | Complement C1r subcomponent heavy chain; C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system; Belongs to the peptidase S1 family. | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. | 0.999 |
| C1R | SCUBE1 | ENSP00000444271 | ENSP00000354080 | Complement C1r subcomponent heavy chain; C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system; Belongs to the peptidase S1 family. | Signal peptide, CUB and EGF-like domain-containing protein 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. | 0.455 |
| C1S | C1R | ENSP00000385035 | ENSP00000444271 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. | Complement C1r subcomponent heavy chain; C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system; Belongs to the peptidase S1 family. | 0.999 |
| C1S | SCUBE1 | ENSP00000385035 | ENSP00000354080 | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. | Signal peptide, CUB and EGF-like domain-containing protein 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. | 0.439 |
| SCUBE1 | C1R | ENSP00000354080 | ENSP00000444271 | Signal peptide, CUB and EGF-like domain-containing protein 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. | Complement C1r subcomponent heavy chain; C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system; Belongs to the peptidase S1 family. | 0.455 |
| SCUBE1 | C1S | ENSP00000354080 | ENSP00000385035 | Signal peptide, CUB and EGF-like domain-containing protein 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. | Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. | 0.439 |
| SCUBE1 | SCUBE3 | ENSP00000354080 | ENSP00000274938 | Signal peptide, CUB and EGF-like domain-containing protein 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. | Signal peptide, CUB and EGF-like domain-containing protein 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression. | 0.789 |
| SCUBE3 | SCUBE1 | ENSP00000274938 | ENSP00000354080 | Signal peptide, CUB and EGF-like domain-containing protein 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression. | Signal peptide, CUB and EGF-like domain-containing protein 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. | 0.789 |
