node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ERG28 | FAXDC2 | ENSP00000256319 | ENSP00000320604 | Ergosterol biosynthesis 28 homolog; Belongs to the ERG28 family. | Fatty acid hydroxylase domain-containing protein 2; Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression. | 0.859 |
ERG28 | FBXO43 | ENSP00000256319 | ENSP00000403293 | Ergosterol biosynthesis 28 homolog; Belongs to the ERG28 family. | F-box only protein 43; Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable). | 0.615 |
ERG28 | FDFT1 | ENSP00000256319 | ENSP00000491537 | Ergosterol biosynthesis 28 homolog; Belongs to the ERG28 family. | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1; Belongs to the phytoene/squalene synthase family. | 0.984 |
ERG28 | HSD17B7 | ENSP00000256319 | ENSP00000254521 | Ergosterol biosynthesis 28 homolog; Belongs to the ERG28 family. | 3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. | 0.988 |
ERG28 | LSS | ENSP00000256319 | ENSP00000380837 | Ergosterol biosynthesis 28 homolog; Belongs to the ERG28 family. | Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. | 0.977 |
ERG28 | RGS22 | ENSP00000256319 | ENSP00000354109 | Ergosterol biosynthesis 28 homolog; Belongs to the ERG28 family. | Regulator of G-protein signaling 22; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. | 0.615 |
ERG28 | SC5D | ENSP00000256319 | ENSP00000264027 | Ergosterol biosynthesis 28 homolog; Belongs to the ERG28 family. | Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol; Belongs to the sterol desaturase family. | 0.989 |
ERG28 | SIGMAR1 | ENSP00000256319 | ENSP00000277010 | Ergosterol biosynthesis 28 homolog; Belongs to the ERG28 family. | Sigma non-opioid intracellular receptor 1; Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. [...] | 0.983 |
FAXDC2 | ERG28 | ENSP00000320604 | ENSP00000256319 | Fatty acid hydroxylase domain-containing protein 2; Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression. | Ergosterol biosynthesis 28 homolog; Belongs to the ERG28 family. | 0.859 |
FAXDC2 | FBXO43 | ENSP00000320604 | ENSP00000403293 | Fatty acid hydroxylase domain-containing protein 2; Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression. | F-box only protein 43; Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable). | 0.491 |
FAXDC2 | FDFT1 | ENSP00000320604 | ENSP00000491537 | Fatty acid hydroxylase domain-containing protein 2; Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression. | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1; Belongs to the phytoene/squalene synthase family. | 0.885 |
FAXDC2 | HSD17B7 | ENSP00000320604 | ENSP00000254521 | Fatty acid hydroxylase domain-containing protein 2; Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression. | 3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. | 0.912 |
FAXDC2 | LSS | ENSP00000320604 | ENSP00000380837 | Fatty acid hydroxylase domain-containing protein 2; Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression. | Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. | 0.876 |
FAXDC2 | RGS22 | ENSP00000320604 | ENSP00000354109 | Fatty acid hydroxylase domain-containing protein 2; Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression. | Regulator of G-protein signaling 22; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. | 0.493 |
FAXDC2 | SC5D | ENSP00000320604 | ENSP00000264027 | Fatty acid hydroxylase domain-containing protein 2; Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression. | Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol; Belongs to the sterol desaturase family. | 0.965 |
FAXDC2 | SIGMAR1 | ENSP00000320604 | ENSP00000277010 | Fatty acid hydroxylase domain-containing protein 2; Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression. | Sigma non-opioid intracellular receptor 1; Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. [...] | 0.888 |
FBXO43 | ERG28 | ENSP00000403293 | ENSP00000256319 | F-box only protein 43; Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable). | Ergosterol biosynthesis 28 homolog; Belongs to the ERG28 family. | 0.615 |
FBXO43 | FAXDC2 | ENSP00000403293 | ENSP00000320604 | F-box only protein 43; Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable). | Fatty acid hydroxylase domain-containing protein 2; Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression. | 0.491 |
FBXO43 | FDFT1 | ENSP00000403293 | ENSP00000491537 | F-box only protein 43; Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable). | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1; Belongs to the phytoene/squalene synthase family. | 0.648 |
FBXO43 | HSD17B7 | ENSP00000403293 | ENSP00000254521 | F-box only protein 43; Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable). | 3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. | 0.616 |