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C11orf80 protein (human) - STRING interaction network
"C11orf80" - Type 2 DNA topoisomerase 6 subunit B-like in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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C11orf80Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles (572 aa)    
Predicted Functional Partners:
OR4K14
Olfactory receptor 4K14; Odorant receptor; Olfactory receptors, family 4 (310 aa)
           
  0.726
OR4N5
Olfactory receptor 4N5; Odorant receptor; Olfactory receptors, family 4 (308 aa)
           
  0.712
TMEM132C
Transmembrane protein 132C; Protein phosphatase 1 regulatory subunits (1108 aa)
           
  0.683
ZNF473
Zinc finger protein 473; Involved in histone 3’-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3’-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases; Zinc fingers C2H2-type (871 aa)
           
  0.668
FAM122C
Protein FAM122C; Family with sequence similarity 122C (195 aa)
           
  0.642
KLHL4
Kelch-like protein 4; Kelch like family member 4; BTB domain containing (720 aa)
           
  0.636
SPO11
Meiotic recombination protein SPO11; Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (396 aa)
       
 
  0.622
CCDC85A
Coiled-coil domain containing 85A; Belongs to the CCDC85 family (553 aa)
           
  0.600
RCE1
CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (329 aa)
 
            0.574
PABPC5
Polyadenylate-binding protein 5; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity); RNA binding motif containing (382 aa)
           
  0.572
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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