node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APP | CTRB1 | ENSP00000284981 | ENSP00000354294 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis- inducing pathways such as those mediated by G(O) and JIP. Inhibits [...] | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | 0.645 |
APP | CTRB2 | ENSP00000284981 | ENSP00000303963 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis- inducing pathways such as those mediated by G(O) and JIP. Inhibits [...] | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | 0.649 |
APP | PRSS1 | ENSP00000284981 | ENSP00000308720 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis- inducing pathways such as those mediated by G(O) and JIP. Inhibits [...] | Alpha-trypsin chain 1; Has activity against the synthetic substrates Boc-Phe-Ser- Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg- Mec. The single-chain form is more active than the two-chain form against all of these substrates; Belongs to the peptidase S1 family. | 0.822 |
APP | PRSS2 | ENSP00000284981 | ENSP00000488437 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis- inducing pathways such as those mediated by G(O) and JIP. Inhibits [...] | Trypsin-2; In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family. | 0.804 |
APP | PRSS3 | ENSP00000284981 | ENSP00000354280 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis- inducing pathways such as those mediated by G(O) and JIP. Inhibits [...] | Trypsin-3; Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. Belongs to the peptidase S1 family. | 0.843 |
CTRB1 | APP | ENSP00000354294 | ENSP00000284981 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis- inducing pathways such as those mediated by G(O) and JIP. Inhibits [...] | 0.645 |
CTRB1 | CTRB2 | ENSP00000354294 | ENSP00000303963 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | 0.949 |
CTRB1 | PRSS1 | ENSP00000354294 | ENSP00000308720 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | Alpha-trypsin chain 1; Has activity against the synthetic substrates Boc-Phe-Ser- Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg- Mec. The single-chain form is more active than the two-chain form against all of these substrates; Belongs to the peptidase S1 family. | 0.863 |
CTRB1 | PRSS2 | ENSP00000354294 | ENSP00000488437 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | Trypsin-2; In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family. | 0.720 |
CTRB1 | PRSS3 | ENSP00000354294 | ENSP00000354280 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | Trypsin-3; Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. Belongs to the peptidase S1 family. | 0.798 |
CTRB1 | SPINK1 | ENSP00000354294 | ENSP00000296695 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin- catalyzed premature activation of zymogens (By similarity). | 0.885 |
CTRB1 | TFPI | ENSP00000354294 | ENSP00000233156 | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | Tissue factor pathway inhibitor; Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. | 0.679 |
CTRB2 | APP | ENSP00000303963 | ENSP00000284981 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis- inducing pathways such as those mediated by G(O) and JIP. Inhibits [...] | 0.649 |
CTRB2 | CTRB1 | ENSP00000303963 | ENSP00000354294 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | Chymotrypsinogen B1; Belongs to the peptidase S1 family. | 0.949 |
CTRB2 | PRSS1 | ENSP00000303963 | ENSP00000308720 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | Alpha-trypsin chain 1; Has activity against the synthetic substrates Boc-Phe-Ser- Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg- Mec. The single-chain form is more active than the two-chain form against all of these substrates; Belongs to the peptidase S1 family. | 0.859 |
CTRB2 | PRSS2 | ENSP00000303963 | ENSP00000488437 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | Trypsin-2; In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family. | 0.530 |
CTRB2 | PRSS3 | ENSP00000303963 | ENSP00000354280 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | Trypsin-3; Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. Belongs to the peptidase S1 family. | 0.801 |
CTRB2 | SPINK1 | ENSP00000303963 | ENSP00000296695 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin- catalyzed premature activation of zymogens (By similarity). | 0.886 |
CTRB2 | TFPI | ENSP00000303963 | ENSP00000233156 | Chymotrypsinogen B2; Belongs to the peptidase S1 family. | Tissue factor pathway inhibitor; Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. | 0.683 |
DEFA5 | PRSS2 | ENSP00000329890 | ENSP00000488437 | Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. | Trypsin-2; In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family. | 0.774 |