| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DUSP11 | DUSP27 | ENSP00000272444 | ENSP00000354483 | RNA/RNP complex-1-interacting phosphatase; Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.553 |
| DUSP27 | DUSP11 | ENSP00000354483 | ENSP00000272444 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | RNA/RNP complex-1-interacting phosphatase; Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.553 |
| DUSP27 | EFHB | ENSP00000354483 | ENSP00000295824 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus. | 0.553 |
| DUSP27 | KLHL38 | ENSP00000354483 | ENSP00000321475 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Kelch-like protein 38; Kelch like family member 38. | 0.563 |
| DUSP27 | LRFN4 | ENSP00000354483 | ENSP00000312535 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Leucine-rich repeat and fibronectin type-III domain-containing protein 4; Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity). Belongs to the LRFN family. | 0.407 |
| DUSP27 | MSX2 | ENSP00000354483 | ENSP00000239243 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter; Belongs to the Msh homeobox family. | 0.459 |
| DUSP27 | PGRMC1 | ENSP00000354483 | ENSP00000217971 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Membrane-associated progesterone receptor component 1; Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Belongs to the cytochrome b5 family. MAPR subfamily. | 0.457 |
| DUSP27 | TRDN | ENSP00000354483 | ENSP00000333984 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Triadin; Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | 0.443 |
| DUSP27 | TTI2 | ENSP00000354483 | ENSP00000478396 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | TELO2-interacting protein 2; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. | 0.420 |
| DUSP27 | YIF1B | ENSP00000354483 | ENSP00000343435 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein. | 0.460 |
| EFHB | DUSP27 | ENSP00000295824 | ENSP00000354483 | EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus. | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.553 |
| EFHB | LRFN4 | ENSP00000295824 | ENSP00000312535 | EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus. | Leucine-rich repeat and fibronectin type-III domain-containing protein 4; Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity). Belongs to the LRFN family. | 0.492 |
| KLHL38 | DUSP27 | ENSP00000321475 | ENSP00000354483 | Kelch-like protein 38; Kelch like family member 38. | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.563 |
| LRFN4 | DUSP27 | ENSP00000312535 | ENSP00000354483 | Leucine-rich repeat and fibronectin type-III domain-containing protein 4; Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity). Belongs to the LRFN family. | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.407 |
| LRFN4 | EFHB | ENSP00000312535 | ENSP00000295824 | Leucine-rich repeat and fibronectin type-III domain-containing protein 4; Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity). Belongs to the LRFN family. | EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus. | 0.492 |
| MSX2 | DUSP27 | ENSP00000239243 | ENSP00000354483 | Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter; Belongs to the Msh homeobox family. | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.459 |
| PGRMC1 | DUSP27 | ENSP00000217971 | ENSP00000354483 | Membrane-associated progesterone receptor component 1; Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Belongs to the cytochrome b5 family. MAPR subfamily. | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.457 |
| TRDN | DUSP27 | ENSP00000333984 | ENSP00000354483 | Triadin; Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.443 |
| TTI2 | DUSP27 | ENSP00000478396 | ENSP00000354483 | TELO2-interacting protein 2; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.420 |
| YIF1B | DUSP27 | ENSP00000343435 | ENSP00000354483 | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein. | Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.460 |
