node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD35 | PHLDB1 | ENSP00000347802 | ENSP00000354498 | Ankyrin repeat domain 35. | Pleckstrin homology like domain family B member 1. | 0.508 |
ARCN1 | PHLDB1 | ENSP00000264028 | ENSP00000354498 | Coatomer subunit delta; Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP- binding proteins; the [...] | Pleckstrin homology like domain family B member 1. | 0.474 |
C2orf80 | PHLDB1 | ENSP00000343171 | ENSP00000354498 | Uncharacterized protein C2orf80; Chromosome 2 open reading frame 80. | Pleckstrin homology like domain family B member 1. | 0.433 |
C2orf80 | TMEM25 | ENSP00000343171 | ENSP00000431548 | Uncharacterized protein C2orf80; Chromosome 2 open reading frame 80. | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | 0.418 |
CDKN2B | PHLDB1 | ENSP00000276925 | ENSP00000354498 | Cyclin-dependent kinase 4 inhibitor B; Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | Pleckstrin homology like domain family B member 1. | 0.571 |
CDKN2B | RTEL1 | ENSP00000276925 | ENSP00000353332 | Cyclin-dependent kinase 4 inhibitor B; Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] | 0.437 |
CDKN2B | TERT | ENSP00000276925 | ENSP00000309572 | Cyclin-dependent kinase 4 inhibitor B; Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.652 |
DDX6 | PHLDB1 | ENSP00000478754 | ENSP00000354498 | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | Pleckstrin homology like domain family B member 1. | 0.431 |
DDX6 | TREH | ENSP00000478754 | ENSP00000264029 | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | Trehalase; Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose. | 0.408 |
PHLDB1 | ANKRD35 | ENSP00000354498 | ENSP00000347802 | Pleckstrin homology like domain family B member 1. | Ankyrin repeat domain 35. | 0.508 |
PHLDB1 | ARCN1 | ENSP00000354498 | ENSP00000264028 | Pleckstrin homology like domain family B member 1. | Coatomer subunit delta; Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP- binding proteins; the [...] | 0.474 |
PHLDB1 | C2orf80 | ENSP00000354498 | ENSP00000343171 | Pleckstrin homology like domain family B member 1. | Uncharacterized protein C2orf80; Chromosome 2 open reading frame 80. | 0.433 |
PHLDB1 | CDKN2B | ENSP00000354498 | ENSP00000276925 | Pleckstrin homology like domain family B member 1. | Cyclin-dependent kinase 4 inhibitor B; Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | 0.571 |
PHLDB1 | DDX6 | ENSP00000354498 | ENSP00000478754 | Pleckstrin homology like domain family B member 1. | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. | 0.431 |
PHLDB1 | PLEK | ENSP00000354498 | ENSP00000234313 | Pleckstrin homology like domain family B member 1. | Pleckstrin; Major protein kinase C substrate of platelets. | 0.613 |
PHLDB1 | RTEL1 | ENSP00000354498 | ENSP00000353332 | Pleckstrin homology like domain family B member 1. | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] | 0.767 |
PHLDB1 | TERT | ENSP00000354498 | ENSP00000309572 | Pleckstrin homology like domain family B member 1. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.573 |
PHLDB1 | TMEM25 | ENSP00000354498 | ENSP00000431548 | Pleckstrin homology like domain family B member 1. | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | 0.455 |
PHLDB1 | TREH | ENSP00000354498 | ENSP00000264029 | Pleckstrin homology like domain family B member 1. | Trehalase; Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose. | 0.582 |
PLEK | PHLDB1 | ENSP00000234313 | ENSP00000354498 | Pleckstrin; Major protein kinase C substrate of platelets. | Pleckstrin homology like domain family B member 1. | 0.613 |