node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DOCK4 | RPS2 | ENSP00000410746 | ENSP00000341885 | Dedicator of cytokinesis protein 4; Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. | Ribosomal protein S2. | 0.977 |
DOCK4 | ZNF277 | ENSP00000410746 | ENSP00000354501 | Dedicator of cytokinesis protein 4; Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. | Zinc finger protein 277; May be involved in transcriptional regulation; Belongs to the ZNF277 family. | 0.588 |
GNGT1 | ZNF277 | ENSP00000248572 | ENSP00000354501 | Guanine nucleotide-binding protein G(T) subunit gamma-T1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Zinc finger protein 277; May be involved in transcriptional regulation; Belongs to the ZNF277 family. | 0.711 |
IKZF1 | ZNF277 | ENSP00000331614 | ENSP00000354501 | DNA-binding protein Ikaros; Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus i [...] | Zinc finger protein 277; May be involved in transcriptional regulation; Belongs to the ZNF277 family. | 0.548 |
PDCD2 | PDCD2L | ENSP00000439467 | ENSP00000246535 | Programmed cell death protein 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation. | Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase. | 0.447 |
PDCD2 | RPS2 | ENSP00000439467 | ENSP00000341885 | Programmed cell death protein 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation. | Ribosomal protein S2. | 0.722 |
PDCD2 | ZNF277 | ENSP00000439467 | ENSP00000354501 | Programmed cell death protein 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation. | Zinc finger protein 277; May be involved in transcriptional regulation; Belongs to the ZNF277 family. | 0.700 |
PDCD2L | PDCD2 | ENSP00000246535 | ENSP00000439467 | Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase. | Programmed cell death protein 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation. | 0.447 |
PDCD2L | RPS2 | ENSP00000246535 | ENSP00000341885 | Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase. | Ribosomal protein S2. | 0.769 |
PDCD2L | ZNF277 | ENSP00000246535 | ENSP00000354501 | Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase. | Zinc finger protein 277; May be involved in transcriptional regulation; Belongs to the ZNF277 family. | 0.516 |
RPS2 | DOCK4 | ENSP00000341885 | ENSP00000410746 | Ribosomal protein S2. | Dedicator of cytokinesis protein 4; Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. | 0.977 |
RPS2 | PDCD2 | ENSP00000341885 | ENSP00000439467 | Ribosomal protein S2. | Programmed cell death protein 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation. | 0.722 |
RPS2 | PDCD2L | ENSP00000341885 | ENSP00000246535 | Ribosomal protein S2. | Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase. | 0.769 |
RPS2 | ZNF277 | ENSP00000341885 | ENSP00000354501 | Ribosomal protein S2. | Zinc finger protein 277; May be involved in transcriptional regulation; Belongs to the ZNF277 family. | 0.633 |
RSRC2 | TMEM186 | ENSP00000330188 | ENSP00000331640 | Arginine and serine rich coiled-coil 2; Belongs to the RSRC2 family. | Transmembrane protein 186. | 0.454 |
RSRC2 | ZNF277 | ENSP00000330188 | ENSP00000354501 | Arginine and serine rich coiled-coil 2; Belongs to the RSRC2 family. | Zinc finger protein 277; May be involved in transcriptional regulation; Belongs to the ZNF277 family. | 0.491 |
STX19 | ZNF277 | ENSP00000320679 | ENSP00000354501 | Syntaxin-19; Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR); Belongs to the syntaxin family. | Zinc finger protein 277; May be involved in transcriptional regulation; Belongs to the ZNF277 family. | 0.469 |
TMEM186 | RSRC2 | ENSP00000331640 | ENSP00000330188 | Transmembrane protein 186. | Arginine and serine rich coiled-coil 2; Belongs to the RSRC2 family. | 0.454 |
TMEM186 | TMEM258 | ENSP00000331640 | ENSP00000443216 | Transmembrane protein 186. | Transmembrane protein 258; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are requ [...] | 0.495 |
TMEM186 | ZNF277 | ENSP00000331640 | ENSP00000354501 | Transmembrane protein 186. | Zinc finger protein 277; May be involved in transcriptional regulation; Belongs to the ZNF277 family. | 0.526 |