node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGL | AMY2A | ENSP00000294724 | ENSP00000481450 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Pancreatic alpha-amylase; Amylase alpha 2A. | 0.961 |
AGL | AMY2B | ENSP00000294724 | ENSP00000354610 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Amylase alpha 2B; Belongs to the glycosyl hydrolase 13 family. | 0.962 |
AGL | GAA | ENSP00000294724 | ENSP00000305692 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | 70 kDa lysosomal alpha-glucosidase; Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans. | 0.581 |
AGL | GBE1 | ENSP00000294724 | ENSP00000410833 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | 1,4-alpha-glucan-branching enzyme; Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule (Probable); Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. | 0.993 |
AGL | MGAM | ENSP00000294724 | ENSP00000447378 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Maltase-glucoamylase, intestinal; May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing. | 0.960 |
AGL | MGAM2 | ENSP00000294724 | ENSP00000420449 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Maltase-glucoamylase 2. | 0.939 |
AGL | PYGB | ENSP00000294724 | ENSP00000216962 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Glycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.999 |
AGL | PYGL | ENSP00000294724 | ENSP00000216392 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Glycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.997 |
AGL | PYGM | ENSP00000294724 | ENSP00000164139 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Glycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.997 |
AGL | SI | ENSP00000294724 | ENSP00000264382 | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | Sucrase-isomaltase, intestinal; Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides; Belongs to the glycosyl hydrolase 31 family. | 0.575 |
AMY2A | AGL | ENSP00000481450 | ENSP00000294724 | Pancreatic alpha-amylase; Amylase alpha 2A. | Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. | 0.961 |
AMY2A | AMY2B | ENSP00000481450 | ENSP00000354610 | Pancreatic alpha-amylase; Amylase alpha 2A. | Amylase alpha 2B; Belongs to the glycosyl hydrolase 13 family. | 0.960 |
AMY2A | GAA | ENSP00000481450 | ENSP00000305692 | Pancreatic alpha-amylase; Amylase alpha 2A. | 70 kDa lysosomal alpha-glucosidase; Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans. | 0.956 |
AMY2A | GBE1 | ENSP00000481450 | ENSP00000410833 | Pancreatic alpha-amylase; Amylase alpha 2A. | 1,4-alpha-glucan-branching enzyme; Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule (Probable); Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. | 0.977 |
AMY2A | MGAM | ENSP00000481450 | ENSP00000447378 | Pancreatic alpha-amylase; Amylase alpha 2A. | Maltase-glucoamylase, intestinal; May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing. | 0.998 |
AMY2A | MGAM2 | ENSP00000481450 | ENSP00000420449 | Pancreatic alpha-amylase; Amylase alpha 2A. | Maltase-glucoamylase 2. | 0.998 |
AMY2A | PYGB | ENSP00000481450 | ENSP00000216962 | Pancreatic alpha-amylase; Amylase alpha 2A. | Glycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.972 |
AMY2A | PYGL | ENSP00000481450 | ENSP00000216392 | Pancreatic alpha-amylase; Amylase alpha 2A. | Glycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.972 |
AMY2A | PYGM | ENSP00000481450 | ENSP00000164139 | Pancreatic alpha-amylase; Amylase alpha 2A. | Glycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.970 |
AMY2A | SI | ENSP00000481450 | ENSP00000264382 | Pancreatic alpha-amylase; Amylase alpha 2A. | Sucrase-isomaltase, intestinal; Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides; Belongs to the glycosyl hydrolase 31 family. | 0.993 |