Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]

Coiled-coil domain containing 186.

Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]

RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

Coiled-coil domain containing 183.

RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

Coiled-coil domain containing 183.

TATA element modulatory factor; Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).

Coiled-coil domain containing 186.

Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]

Coiled-coil domain containing 186.

Islet cell autoantigen 1; May play a role in neurotransmitter secretion.

Coiled-coil domain containing 186.

RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

Coiled-coil domain containing 186.

TATA element modulatory factor; Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).

Coiled-coil domain containing 186.

Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).

Coiled-coil domain containing 186.

Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome- derived carriers to the TGN. Acts as component of the EARP complex [...]

Coiled-coil domain containing 96.

Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46.

Coiled-coil domain containing 96.

RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

Glycerophosphocholine cholinephosphodiesterase ENPP6; Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet- activating factor (PAF) and lysoPAF, but not other lysophospholipids (By similarity); Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

Islet cell autoantigen 1; May play a role in neurotransmitter secretion.

Coiled-coil domain containing 186.

Islet cell autoantigen 1; May play a role in neurotransmitter secretion.

RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46.

Coiled-coil domain containing 96.

Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46.

RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]

RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

Coiled-coil domain containing 183.

RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

Coiled-coil domain containing 186.