| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CSKMT | FAM163A | ENSP00000431287 | ENSP00000354891 | Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial; Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria. Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methly group per binding event. | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | 0.448 |
| CST9L | FAM163A | ENSP00000366178 | ENSP00000354891 | Cystatin-9-like; Cystatin 9 like; Belongs to the cystatin family. | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | 0.474 |
| DCAF13 | FAM163A | ENSP00000297579 | ENSP00000354891 | DDB1- and CUL4-associated factor 13; Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF13/WDSOF1 family. | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | 0.480 |
| FAM163A | CSKMT | ENSP00000354891 | ENSP00000431287 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial; Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria. Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methly group per binding event. | 0.448 |
| FAM163A | CST9L | ENSP00000354891 | ENSP00000366178 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | Cystatin-9-like; Cystatin 9 like; Belongs to the cystatin family. | 0.474 |
| FAM163A | DCAF13 | ENSP00000354891 | ENSP00000297579 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | DDB1- and CUL4-associated factor 13; Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF13/WDSOF1 family. | 0.480 |
| FAM163A | LRP10 | ENSP00000354891 | ENSP00000352601 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | Low-density lipoprotein receptor-related protein 10; Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity); Belongs to the LDLR family. | 0.668 |
| FAM163A | LRP4 | ENSP00000354891 | ENSP00000367888 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | Low-density lipoprotein receptor-related protein 4; Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the [...] | 0.465 |
| FAM163A | MAMDC2 | ENSP00000354891 | ENSP00000366387 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | MAM domain containing 2. | 0.461 |
| FAM163A | SFN | ENSP00000354891 | ENSP00000340989 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | 14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53; Belongs to the 14-3-3 family. | 0.472 |
| FAM163A | TNNI3K | ENSP00000354891 | ENSP00000322251 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | Serine/threonine-protein kinase TNNI3K; May play a role in cardiac physiology. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | 0.435 |
| FAM163A | TOR1AIP2 | ENSP00000354891 | ENSP00000356584 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | Torsin-1A-interacting protein 2; Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. Belongs to the TOR1AIP family. | 0.472 |
| FAM163A | YWHAE | ENSP00000354891 | ENSP00000264335 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | 14-3-3 protein epsilon; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. | 0.693 |
| LRP10 | FAM163A | ENSP00000352601 | ENSP00000354891 | Low-density lipoprotein receptor-related protein 10; Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity); Belongs to the LDLR family. | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | 0.668 |
| LRP4 | FAM163A | ENSP00000367888 | ENSP00000354891 | Low-density lipoprotein receptor-related protein 4; Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the [...] | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | 0.465 |
| MAMDC2 | FAM163A | ENSP00000366387 | ENSP00000354891 | MAM domain containing 2. | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | 0.461 |
| SFN | FAM163A | ENSP00000340989 | ENSP00000354891 | 14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53; Belongs to the 14-3-3 family. | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | 0.472 |
| SFN | YWHAE | ENSP00000340989 | ENSP00000264335 | 14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53; Belongs to the 14-3-3 family. | 14-3-3 protein epsilon; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. | 0.737 |
| TNNI3K | FAM163A | ENSP00000322251 | ENSP00000354891 | Serine/threonine-protein kinase TNNI3K; May play a role in cardiac physiology. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | 0.435 |
| TOR1AIP2 | FAM163A | ENSP00000356584 | ENSP00000354891 | Torsin-1A-interacting protein 2; Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. Belongs to the TOR1AIP family. | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family. | 0.472 |