node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALPK1 | ALPK2 | ENSP00000498374 | ENSP00000354991 | Alpha-protein kinase 1; Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognizes and binds ADP-D-glycero-beta- D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram- negative and some Gram-positive bacteria. ADP- Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling. May be involved in monosodium urate m [...] | Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling ; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. | 0.570 |
ALPK2 | ALPK1 | ENSP00000354991 | ENSP00000498374 | Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling ; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. | Alpha-protein kinase 1; Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognizes and binds ADP-D-glycero-beta- D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram- negative and some Gram-positive bacteria. ADP- Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling. May be involved in monosodium urate m [...] | 0.570 |
ALPK2 | CDCA2 | ENSP00000354991 | ENSP00000328228 | Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling ; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. | Cell division cycle-associated protein 2; Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. | 0.476 |
ALPK2 | COBLL1 | ENSP00000354991 | ENSP00000487041 | Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling ; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. | Cordon-bleu WH2 repeat protein like 1. | 0.426 |
ALPK2 | EXPH5 | ENSP00000354991 | ENSP00000265843 | Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling ; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking. | 0.521 |
ALPK2 | HYPK | ENSP00000354991 | ENSP00000384474 | Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling ; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. | Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Regulator of the N-terminal acetyltransferase NAA10-NAA15 complex. Has been in one study shown to be required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation. However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N- terminal acetylation. | 0.597 |
ALPK2 | KIAA1614 | ENSP00000354991 | ENSP00000356560 | Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling ; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. | Uncharacterized protein KIAA1614; KIAA1614. | 0.411 |
ALPK2 | NAA15 | ENSP00000354991 | ENSP00000296543 | Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling ; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. | N-alpha-acetyltransferase 15, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. | 0.482 |
ALPK2 | NAA16 | ENSP00000354991 | ENSP00000368716 | Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling ; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. | N-alpha-acetyltransferase 16, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. | 0.608 |
ALPK2 | ZNF831 | ENSP00000354991 | ENSP00000490240 | Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling ; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. | Zinc finger protein 831. | 0.448 |
CDCA2 | ALPK2 | ENSP00000328228 | ENSP00000354991 | Cell division cycle-associated protein 2; Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. | Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling ; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. | 0.476 |
CDCA2 | EXPH5 | ENSP00000328228 | ENSP00000265843 | Cell division cycle-associated protein 2; Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking. | 0.479 |
COBLL1 | ALPK2 | ENSP00000487041 | ENSP00000354991 | Cordon-bleu WH2 repeat protein like 1. | Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling ; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. | 0.426 |
COBLL1 | EXPH5 | ENSP00000487041 | ENSP00000265843 | Cordon-bleu WH2 repeat protein like 1. | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking. | 0.462 |
EXPH5 | ALPK2 | ENSP00000265843 | ENSP00000354991 | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking. | Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling ; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. | 0.521 |
EXPH5 | CDCA2 | ENSP00000265843 | ENSP00000328228 | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking. | Cell division cycle-associated protein 2; Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. | 0.479 |
EXPH5 | COBLL1 | ENSP00000265843 | ENSP00000487041 | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking. | Cordon-bleu WH2 repeat protein like 1. | 0.462 |
EXPH5 | KIAA1614 | ENSP00000265843 | ENSP00000356560 | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking. | Uncharacterized protein KIAA1614; KIAA1614. | 0.414 |
EXPH5 | ZNF831 | ENSP00000265843 | ENSP00000490240 | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking. | Zinc finger protein 831. | 0.505 |
HYPK | ALPK2 | ENSP00000384474 | ENSP00000354991 | Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Regulator of the N-terminal acetyltransferase NAA10-NAA15 complex. Has been in one study shown to be required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation. However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N- terminal acetylation. | Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling ; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. | 0.597 |