node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDH17 | DIPK2A | ENSP00000027335 | ENSP00000320081 | Cadherin-17; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. | Divergent protein kinase domain 2A; May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade; Belongs to the DIPK family. | 0.416 |
CDH17 | FGFR1 | ENSP00000027335 | ENSP00000393312 | Cadherin-17; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 lea [...] | 0.400 |
CDH17 | PCDH18 | ENSP00000027335 | ENSP00000355082 | Cadherin-17; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | 0.642 |
DIPK2A | CDH17 | ENSP00000320081 | ENSP00000027335 | Divergent protein kinase domain 2A; May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade; Belongs to the DIPK family. | Cadherin-17; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. | 0.416 |
DIPK2A | PCDH18 | ENSP00000320081 | ENSP00000355082 | Divergent protein kinase domain 2A; May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade; Belongs to the DIPK family. | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | 0.764 |
FGFR1 | CDH17 | ENSP00000393312 | ENSP00000027335 | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 lea [...] | Cadherin-17; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. | 0.400 |
FGFR1 | PCDH18 | ENSP00000393312 | ENSP00000355082 | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 lea [...] | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | 0.424 |
LCK | PCDH18 | ENSP00000477713 | ENSP00000355082 | Tyrosine-protein kinase Lck; Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T- cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen- bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein [...] | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | 0.415 |
LPAR1 | PCDH18 | ENSP00000363553 | ENSP00000355082 | Lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C [...] | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | 0.454 |
LPAR1 | TM4SF1 | ENSP00000363553 | ENSP00000304277 | Lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C [...] | Transmembrane 4 L six family member 1; Belongs to the L6 tetraspanin family. | 0.435 |
LYSMD3 | PCDH18 | ENSP00000314518 | ENSP00000355082 | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | 0.457 |
PCDH18 | CDH17 | ENSP00000355082 | ENSP00000027335 | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | Cadherin-17; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. | 0.642 |
PCDH18 | DIPK2A | ENSP00000355082 | ENSP00000320081 | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | Divergent protein kinase domain 2A; May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade; Belongs to the DIPK family. | 0.764 |
PCDH18 | FGFR1 | ENSP00000355082 | ENSP00000393312 | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 lea [...] | 0.424 |
PCDH18 | LCK | ENSP00000355082 | ENSP00000477713 | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | Tyrosine-protein kinase Lck; Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T- cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen- bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein [...] | 0.415 |
PCDH18 | LPAR1 | ENSP00000355082 | ENSP00000363553 | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | Lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C [...] | 0.454 |
PCDH18 | LYSMD3 | ENSP00000355082 | ENSP00000314518 | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity. | 0.457 |
PCDH18 | PCDHGB1 | ENSP00000355082 | ENSP00000429273 | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | Protocadherin gamma-B1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. | 0.426 |
PCDH18 | PKHD1 | ENSP00000355082 | ENSP00000360158 | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | Fibrocystin; May be required for correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly. May be a receptor protein that acts in collecting-duct and biliary differentiation. | 0.437 |
PCDH18 | SIX1 | ENSP00000355082 | ENSP00000494686 | Protocadherin-18; Potential calcium-dependent cell-adhesion protein. | Homeobox protein SIX1; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of nume [...] | 0.415 |