TIGD4 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARFIP1	TIGD4	ENSP00000296557	ENSP00000355162	Arfaptin-1; Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.	Tigger transposable element derived 4.	0.623
ENOX1	TIGD4	ENSP00000261488	ENSP00000355162	Protein disulfide-thiol oxidoreductase; Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.	Tigger transposable element derived 4.	0.470
HARBI1	NAIF1	ENSP00000317743	ENSP00000362170	Putative nuclease HARBI1; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.	Nuclear apoptosis-inducing factor 1; Induces apoptosis; Belongs to the NAIF1 family.	0.940
HARBI1	TIGD4	ENSP00000317743	ENSP00000355162	Putative nuclease HARBI1; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.	Tigger transposable element derived 4.	0.532
HARBI1	TIGD5	ENSP00000317743	ENSP00000421489	Putative nuclease HARBI1; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.	Tigger transposable element derived 5.	0.550
KIFBP	TIGD4	ENSP00000354848	ENSP00000355162	KIF-binding protein; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development; Belongs to the KIF-binding protein family.	Tigger transposable element derived 4.	0.772
LIN37	TIGD4	ENSP00000301159	ENSP00000355162	Protein lin-37 homolog; Lin-37 DREAM MuvB core complex component.	Tigger transposable element derived 4.	0.472
MCM3AP	RNF123	ENSP00000291688	ENSP00000328287	Germinal-center associated nuclear protein; [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations. Belongs to the SAC3 family.	E3 ubiquitin-protein ligase RNF123; Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS.	0.496
MCM3AP	TIGD4	ENSP00000291688	ENSP00000355162	Germinal-center associated nuclear protein; [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations. Belongs to the SAC3 family.	Tigger transposable element derived 4.	0.463
NAIF1	HARBI1	ENSP00000362170	ENSP00000317743	Nuclear apoptosis-inducing factor 1; Induces apoptosis; Belongs to the NAIF1 family.	Putative nuclease HARBI1; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.	0.940
NAIF1	TIGD4	ENSP00000362170	ENSP00000355162	Nuclear apoptosis-inducing factor 1; Induces apoptosis; Belongs to the NAIF1 family.	Tigger transposable element derived 4.	0.517
NAIF1	TIGD5	ENSP00000362170	ENSP00000421489	Nuclear apoptosis-inducing factor 1; Induces apoptosis; Belongs to the NAIF1 family.	Tigger transposable element derived 5.	0.541
RNF123	MCM3AP	ENSP00000328287	ENSP00000291688	E3 ubiquitin-protein ligase RNF123; Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS.	Germinal-center associated nuclear protein; [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations. Belongs to the SAC3 family.	0.496
RNF123	TIGD4	ENSP00000328287	ENSP00000355162	E3 ubiquitin-protein ligase RNF123; Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS.	Tigger transposable element derived 4.	0.457
TIGD4	ARFIP1	ENSP00000355162	ENSP00000296557	Tigger transposable element derived 4.	Arfaptin-1; Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.	0.623
TIGD4	ENOX1	ENSP00000355162	ENSP00000261488	Tigger transposable element derived 4.	Protein disulfide-thiol oxidoreductase; Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.	0.470
TIGD4	HARBI1	ENSP00000355162	ENSP00000317743	Tigger transposable element derived 4.	Putative nuclease HARBI1; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.	0.532
TIGD4	KIFBP	ENSP00000355162	ENSP00000354848	Tigger transposable element derived 4.	KIF-binding protein; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development; Belongs to the KIF-binding protein family.	0.772
TIGD4	LIN37	ENSP00000355162	ENSP00000301159	Tigger transposable element derived 4.	Protein lin-37 homolog; Lin-37 DREAM MuvB core complex component.	0.472
TIGD4	MCM3AP	ENSP00000355162	ENSP00000291688	Tigger transposable element derived 4.	Germinal-center associated nuclear protein; [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations. Belongs to the SAC3 family.	0.463