LRRC10 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BEST3	CCT2	ENSP00000332413	ENSP00000299300	Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family.	T-complex protein 1 subunit beta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable).	0.576
BEST3	LRRC10	ENSP00000332413	ENSP00000355166	Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family.	Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function.	0.629
CCT2	BEST3	ENSP00000299300	ENSP00000332413	T-complex protein 1 subunit beta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable).	Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family.	0.576
CCT2	LRRC10	ENSP00000299300	ENSP00000355166	T-complex protein 1 subunit beta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable).	Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function.	0.654
KERA	LRRC10	ENSP00000266719	ENSP00000355166	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.	Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function.	0.549
KERA	LUM	ENSP00000266719	ENSP00000266718	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.676
KERA	NYX	ENSP00000266719	ENSP00000340328	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.	Nyctalopin.	0.509
KERA	OMD	ENSP00000266719	ENSP00000364700	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.	Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).	0.643
KERA	PRELP	ENSP00000266719	ENSP00000343924	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.	Prolargin; May anchor basement membranes to the underlying connective tissue.	0.561
LRG1	LRRC10	ENSP00000302621	ENSP00000355166	Leucine rich alpha-2-glycoprotein 1.	Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function.	0.531
LRRC10	BEST3	ENSP00000355166	ENSP00000332413	Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function.	Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family.	0.629
LRRC10	CCT2	ENSP00000355166	ENSP00000299300	Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function.	T-complex protein 1 subunit beta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable).	0.654
LRRC10	KERA	ENSP00000355166	ENSP00000266719	Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function.	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.	0.549
LRRC10	LRG1	ENSP00000355166	ENSP00000302621	Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function.	Leucine rich alpha-2-glycoprotein 1.	0.531
LRRC10	LRRC26	ENSP00000355166	ENSP00000360597	Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function.	Leucine-rich repeat-containing protein 26; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.	0.627
LRRC10	LUM	ENSP00000355166	ENSP00000266718	Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function.	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.520
LRRC10	NYX	ENSP00000355166	ENSP00000340328	Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function.	Nyctalopin.	0.531
LRRC10	OMD	ENSP00000355166	ENSP00000364700	Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function.	Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).	0.518
LRRC10	PRELP	ENSP00000355166	ENSP00000343924	Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function.	Prolargin; May anchor basement membranes to the underlying connective tissue.	0.527
LRRC10	RANGRF	ENSP00000355166	ENSP00000226105	Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function.	Ran guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes. Belongs to the MOG1 family.	0.535