| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAMTSL5 | DOK4 | ENSP00000327608 | ENSP00000455566 | ADAMTS-like protein 5; May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM). | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. | 0.515 |
| ADAMTSL5 | TMEM184B | ENSP00000327608 | ENSP00000354441 | ADAMTS-like protein 5; May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM). | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | 0.548 |
| DOK4 | ADAMTSL5 | ENSP00000455566 | ENSP00000327608 | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. | ADAMTS-like protein 5; May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM). | 0.515 |
| DOK4 | TMEM184B | ENSP00000455566 | ENSP00000354441 | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | 0.576 |
| ERGIC3 | TMEM184B | ENSP00000349970 | ENSP00000354441 | Endoplasmic reticulum-Golgi intermediate compartment protein 3; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the ERGIC family. | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | 0.520 |
| ITIH2 | TMEM184B | ENSP00000351190 | ENSP00000354441 | Inter-alpha-trypsin inhibitor heavy chain H2; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes; Belongs to the ITIH family. | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | 0.517 |
| KLHDC8B | TMEM184B | ENSP00000327468 | ENSP00000354441 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | 0.472 |
| LPAR6 | TMEM184B | ENSP00000367691 | ENSP00000354441 | Lysophosphatidic acid receptor 6; Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | 0.449 |
| RPP40 | TMEM184B | ENSP00000369391 | ENSP00000354441 | Ribonuclease P protein subunit p40; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | 0.458 |
| SNIP1 | TMEM184B | ENSP00000296215 | ENSP00000354441 | Smad nuclear-interacting protein 1; Required for pre-mRNA splicing as component of the spliceosome. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | 0.607 |
| SPRY2 | TMEM184B | ENSP00000366306 | ENSP00000354441 | Protein sprouty homolog 2; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Belongs to the sprouty family. | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | 0.484 |
| TLE4 | TMEM184B | ENSP00000365720 | ENSP00000354441 | Transducin-like enhancer protein 4; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity); Belongs to the WD repeat Groucho/TLE family. | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | 0.473 |
| TMEM184B | ADAMTSL5 | ENSP00000354441 | ENSP00000327608 | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | ADAMTS-like protein 5; May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM). | 0.548 |
| TMEM184B | DOK4 | ENSP00000354441 | ENSP00000455566 | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. | 0.576 |
| TMEM184B | ERGIC3 | ENSP00000354441 | ENSP00000349970 | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | Endoplasmic reticulum-Golgi intermediate compartment protein 3; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the ERGIC family. | 0.520 |
| TMEM184B | ITIH2 | ENSP00000354441 | ENSP00000351190 | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | Inter-alpha-trypsin inhibitor heavy chain H2; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes; Belongs to the ITIH family. | 0.517 |
| TMEM184B | KLHDC8B | ENSP00000354441 | ENSP00000327468 | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | 0.472 |
| TMEM184B | LPAR6 | ENSP00000354441 | ENSP00000367691 | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | Lysophosphatidic acid receptor 6; Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. | 0.449 |
| TMEM184B | RPP40 | ENSP00000354441 | ENSP00000369391 | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | Ribonuclease P protein subunit p40; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. | 0.458 |
| TMEM184B | SNIP1 | ENSP00000354441 | ENSP00000296215 | Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family. | Smad nuclear-interacting protein 1; Required for pre-mRNA splicing as component of the spliceosome. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. | 0.607 |
