| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BTBD1 | BTBD2 | ENSP00000261721 | ENSP00000255608 | BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). | BTB/POZ domain-containing protein 2; BTB domain containing 2. | 0.995 |
| BTBD1 | OSGIN1 | ENSP00000261721 | ENSP00000355374 | BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | 0.554 |
| BTBD2 | BTBD1 | ENSP00000255608 | ENSP00000261721 | BTB/POZ domain-containing protein 2; BTB domain containing 2. | BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). | 0.995 |
| BTBD2 | OSGIN1 | ENSP00000255608 | ENSP00000355374 | BTB/POZ domain-containing protein 2; BTB domain containing 2. | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | 0.472 |
| BTBD2 | TP53 | ENSP00000255608 | ENSP00000269305 | BTB/POZ domain-containing protein 2; BTB domain containing 2. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.487 |
| CAPN3 | OSGIN1 | ENSP00000380349 | ENSP00000355374 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | 0.750 |
| GCLM | NQO1 | ENSP00000359258 | ENSP00000319788 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | 0.945 |
| GCLM | OSGIN1 | ENSP00000359258 | ENSP00000355374 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | 0.683 |
| GCLM | SRXN1 | ENSP00000359258 | ENSP00000371388 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. Belongs to the sulfiredoxin family. | 0.789 |
| MEIS2 | OSGIN1 | ENSP00000453793 | ENSP00000355374 | Homeobox protein Meis2; Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in [...] | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | 0.601 |
| NQO1 | GCLM | ENSP00000319788 | ENSP00000359258 | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | 0.945 |
| NQO1 | OSGIN1 | ENSP00000319788 | ENSP00000355374 | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | 0.458 |
| NQO1 | PRKN | ENSP00000319788 | ENSP00000355865 | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'- linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of m [...] | 0.590 |
| NQO1 | SRXN1 | ENSP00000319788 | ENSP00000371388 | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. Belongs to the sulfiredoxin family. | 0.712 |
| NQO1 | TP53 | ENSP00000319788 | ENSP00000269305 | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.995 |
| OSGIN1 | BTBD1 | ENSP00000355374 | ENSP00000261721 | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). | 0.554 |
| OSGIN1 | BTBD2 | ENSP00000355374 | ENSP00000255608 | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | BTB/POZ domain-containing protein 2; BTB domain containing 2. | 0.472 |
| OSGIN1 | CAPN3 | ENSP00000355374 | ENSP00000380349 | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | 0.750 |
| OSGIN1 | GCLM | ENSP00000355374 | ENSP00000359258 | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | 0.683 |
| OSGIN1 | MEIS2 | ENSP00000355374 | ENSP00000453793 | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | Homeobox protein Meis2; Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in [...] | 0.601 |
