| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CAPN3 | OSGIN1 | ENSP00000380349 | ENSP00000355374 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | 0.479 |
| GCLM | NQO1 | ENSP00000359258 | ENSP00000319788 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | 0.949 |
| GCLM | OSGIN1 | ENSP00000359258 | ENSP00000355374 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | 0.550 |
| GCLM | SRXN1 | ENSP00000359258 | ENSP00000371388 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. Belongs to the sulfiredoxin family. | 0.802 |
| GCLM | TXNRD1 | ENSP00000359258 | ENSP00000434516 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Thioredoxin reductase 1, cytoplasmic; Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid. | 0.795 |
| LRIT1 | MANSC4 | ENSP00000361177 | ENSP00000370673 | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction. | MANSC domain containing 4. | 0.625 |
| LRIT1 | OSGIN1 | ENSP00000361177 | ENSP00000355374 | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction. | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | 0.416 |
| MANSC4 | LRIT1 | ENSP00000370673 | ENSP00000361177 | MANSC domain containing 4. | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction. | 0.625 |
| MANSC4 | OSGIN1 | ENSP00000370673 | ENSP00000355374 | MANSC domain containing 4. | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | 0.404 |
| MEIS2 | OSGIN1 | ENSP00000453793 | ENSP00000355374 | Homeobox protein Meis2; Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in [...] | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | 0.415 |
| NQO1 | GCLM | ENSP00000319788 | ENSP00000359258 | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | 0.949 |
| NQO1 | OSGIN1 | ENSP00000319788 | ENSP00000355374 | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | 0.646 |
| NQO1 | SRXN1 | ENSP00000319788 | ENSP00000371388 | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. Belongs to the sulfiredoxin family. | 0.803 |
| NQO1 | TXNRD1 | ENSP00000319788 | ENSP00000434516 | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | Thioredoxin reductase 1, cytoplasmic; Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid. | 0.803 |
| OSGIN1 | CAPN3 | ENSP00000355374 | ENSP00000380349 | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | 0.479 |
| OSGIN1 | GCLM | ENSP00000355374 | ENSP00000359258 | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | 0.550 |
| OSGIN1 | LRIT1 | ENSP00000355374 | ENSP00000361177 | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction. | 0.416 |
| OSGIN1 | MANSC4 | ENSP00000355374 | ENSP00000370673 | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | MANSC domain containing 4. | 0.404 |
| OSGIN1 | MEIS2 | ENSP00000355374 | ENSP00000453793 | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | Homeobox protein Meis2; Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in [...] | 0.415 |
| OSGIN1 | NQO1 | ENSP00000355374 | ENSP00000319788 | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death. | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | 0.646 |
STRING v12.5 is now available!
