| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GOLGA6A | ISLR2 | ENSP00000290438 | ENSP00000355402 | Golgin A6 family member A. | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | 0.509 |
| GOLGA6A | STOML1 | ENSP00000290438 | ENSP00000442478 | Golgin A6 family member A. | Stomatin-like protein 1; May play a role in cholesterol transfer to late endosomes. May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation ; Belongs to the band 7/mec-2 family. | 0.421 |
| GPC3 | ISLR2 | ENSP00000377836 | ENSP00000355402 | Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate. Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligand [...] | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | 0.493 |
| ICAM5 | IL6R | ENSP00000221980 | ENSP00000357470 | Intercellular adhesion molecule 5; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). | Interleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. | 0.640 |
| ICAM5 | ISLR2 | ENSP00000221980 | ENSP00000355402 | Intercellular adhesion molecule 5; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | 0.695 |
| IGFBP7 | IL6R | ENSP00000295666 | ENSP00000357470 | Insulin-like growth factor-binding protein 7; Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. | Interleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. | 0.660 |
| IGFBP7 | ISLR2 | ENSP00000295666 | ENSP00000355402 | Insulin-like growth factor-binding protein 7; Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | 0.632 |
| IGFBPL1 | IL6R | ENSP00000366923 | ENSP00000357470 | Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein. | Interleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. | 0.622 |
| IGFBPL1 | ISLR2 | ENSP00000366923 | ENSP00000355402 | Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein. | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | 0.690 |
| IL6R | ICAM5 | ENSP00000357470 | ENSP00000221980 | Interleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. | Intercellular adhesion molecule 5; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). | 0.640 |
| IL6R | IGFBP7 | ENSP00000357470 | ENSP00000295666 | Interleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. | Insulin-like growth factor-binding protein 7; Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. | 0.660 |
| IL6R | IGFBPL1 | ENSP00000357470 | ENSP00000366923 | Interleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. | Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein. | 0.622 |
| IL6R | ISLR2 | ENSP00000357470 | ENSP00000355402 | Interleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | 0.635 |
| IL6R | LTF | ENSP00000357470 | ENSP00000231751 | Interleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. | Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG- binding site. Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows pr [...] | 0.694 |
| ISLR2 | GOLGA6A | ENSP00000355402 | ENSP00000290438 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | Golgin A6 family member A. | 0.509 |
| ISLR2 | GPC3 | ENSP00000355402 | ENSP00000377836 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate. Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligand [...] | 0.493 |
| ISLR2 | ICAM5 | ENSP00000355402 | ENSP00000221980 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | Intercellular adhesion molecule 5; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). | 0.695 |
| ISLR2 | IGFBP7 | ENSP00000355402 | ENSP00000295666 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | Insulin-like growth factor-binding protein 7; Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. | 0.632 |
| ISLR2 | IGFBPL1 | ENSP00000355402 | ENSP00000366923 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein. | 0.690 |
| ISLR2 | IL6R | ENSP00000355402 | ENSP00000357470 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | Interleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. | 0.635 |
