node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADGRL1 | ISLR2 | ENSP00000340688 | ENSP00000355402 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | 0.515 |
ADGRL2 | ISLR2 | ENSP00000359765 | ENSP00000355402 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | 0.514 |
ADGRL3 | EPHA3 | ENSP00000422533 | ENSP00000337451 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in ca [...] | 0.448 |
ADGRL3 | ISLR2 | ENSP00000422533 | ENSP00000355402 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | 0.514 |
CCDC33 | GOLGA6A | ENSP00000381795 | ENSP00000290438 | Coiled-coil domain containing 33. | Golgin A6 family member A. | 0.419 |
CCDC33 | ISLR2 | ENSP00000381795 | ENSP00000355402 | Coiled-coil domain containing 33. | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | 0.482 |
CCDC33 | UBL7 | ENSP00000381795 | ENSP00000457703 | Coiled-coil domain containing 33. | Ubiquitin-like protein 7; Ubiquitin like 7. | 0.661 |
EPHA3 | ADGRL3 | ENSP00000337451 | ENSP00000422533 | Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in ca [...] | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | 0.448 |
EPHA3 | ISLR2 | ENSP00000337451 | ENSP00000355402 | Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in ca [...] | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | 0.433 |
GOLGA6A | CCDC33 | ENSP00000290438 | ENSP00000381795 | Golgin A6 family member A. | Coiled-coil domain containing 33. | 0.419 |
GOLGA6A | ISLR2 | ENSP00000290438 | ENSP00000355402 | Golgin A6 family member A. | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | 0.507 |
GOLGA6A | UBL7 | ENSP00000290438 | ENSP00000457703 | Golgin A6 family member A. | Ubiquitin-like protein 7; Ubiquitin like 7. | 0.443 |
ISLR2 | ADGRL1 | ENSP00000355402 | ENSP00000340688 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | 0.515 |
ISLR2 | ADGRL2 | ENSP00000355402 | ENSP00000359765 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | 0.514 |
ISLR2 | ADGRL3 | ENSP00000355402 | ENSP00000422533 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | 0.514 |
ISLR2 | CCDC33 | ENSP00000355402 | ENSP00000381795 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | Coiled-coil domain containing 33. | 0.482 |
ISLR2 | EPHA3 | ENSP00000355402 | ENSP00000337451 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in ca [...] | 0.433 |
ISLR2 | GOLGA6A | ENSP00000355402 | ENSP00000290438 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | Golgin A6 family member A. | 0.507 |
ISLR2 | NTN3 | ENSP00000355402 | ENSP00000293973 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | Netrin-3; Netrins control guidance of CNS commissural axons and peripheral motor axons. | 0.428 |
ISLR2 | RNF26 | ENSP00000355402 | ENSP00000312439 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development. | E3 ubiquitin-protein ligase RNF26; E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1. Ubiquitinated SQSTM1 attracts specific vesicle- associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating th [...] | 0.428 |