node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CA10 | WDR64 | ENSP00000405388 | ENSP00000355510 | Carbonic anhydrase-related protein 10; Does not have a catalytic activity; Belongs to the alpha-carbonic anhydrase family. | WD repeat domain 64. | 0.525 |
CCDC30 | HMGXB4 | ENSP00000339280 | ENSP00000216106 | Coiled-coil domain containing 30; Belongs to the prefoldin subunit beta family. | HMG domain-containing protein 4; Negatively regulates Wnt/beta-catenin signaling during development. | 0.535 |
CCDC30 | NAGPA | ENSP00000339280 | ENSP00000310998 | Coiled-coil domain containing 30; Belongs to the prefoldin subunit beta family. | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Catalyzes the second step in the formation of the mannose 6- phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. | 0.408 |
CCDC30 | WDR64 | ENSP00000339280 | ENSP00000355510 | Coiled-coil domain containing 30; Belongs to the prefoldin subunit beta family. | WD repeat domain 64. | 0.619 |
HMGXB4 | CCDC30 | ENSP00000216106 | ENSP00000339280 | HMG domain-containing protein 4; Negatively regulates Wnt/beta-catenin signaling during development. | Coiled-coil domain containing 30; Belongs to the prefoldin subunit beta family. | 0.535 |
HMGXB4 | WDR64 | ENSP00000216106 | ENSP00000355510 | HMG domain-containing protein 4; Negatively regulates Wnt/beta-catenin signaling during development. | WD repeat domain 64. | 0.457 |
NAGPA | CCDC30 | ENSP00000310998 | ENSP00000339280 | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Catalyzes the second step in the formation of the mannose 6- phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. | Coiled-coil domain containing 30; Belongs to the prefoldin subunit beta family. | 0.408 |
NAGPA | RERE | ENSP00000310998 | ENSP00000338629 | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Catalyzes the second step in the formation of the mannose 6- phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. | Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. | 0.473 |
NAGPA | WDR64 | ENSP00000310998 | ENSP00000355510 | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Catalyzes the second step in the formation of the mannose 6- phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. | WD repeat domain 64. | 0.578 |
OPN3 | WDR64 | ENSP00000355512 | ENSP00000355510 | Opsin-3; May play a role in encephalic photoreception; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. | WD repeat domain 64. | 0.582 |
PLD5 | WDR64 | ENSP00000440896 | ENSP00000355510 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | WD repeat domain 64. | 0.508 |
RERE | NAGPA | ENSP00000338629 | ENSP00000310998 | Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Catalyzes the second step in the formation of the mannose 6- phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. | 0.473 |
RERE | WDR64 | ENSP00000338629 | ENSP00000355510 | Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. | WD repeat domain 64. | 0.486 |
RGS7 | WDR64 | ENSP00000355523 | ENSP00000355510 | Regulator of G-protein signaling 7; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. | WD repeat domain 64. | 0.530 |
ST6GAL2 | WDR64 | ENSP00000386942 | ENSP00000355510 | Beta-galactoside alpha-2,6-sialyltransferase 2; Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6- sialyltransferase activity toward oligosaccharides that have the Gal- beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids; Belongs to the glycosyltransferase 29 family. | WD repeat domain 64. | 0.480 |
UXS1 | WDR64 | ENSP00000283148 | ENSP00000355510 | UDP-glucuronic acid decarboxylase 1; Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis. | WD repeat domain 64. | 0.516 |
WDR64 | CA10 | ENSP00000355510 | ENSP00000405388 | WD repeat domain 64. | Carbonic anhydrase-related protein 10; Does not have a catalytic activity; Belongs to the alpha-carbonic anhydrase family. | 0.525 |
WDR64 | CCDC30 | ENSP00000355510 | ENSP00000339280 | WD repeat domain 64. | Coiled-coil domain containing 30; Belongs to the prefoldin subunit beta family. | 0.619 |
WDR64 | HMGXB4 | ENSP00000355510 | ENSP00000216106 | WD repeat domain 64. | HMG domain-containing protein 4; Negatively regulates Wnt/beta-catenin signaling during development. | 0.457 |
WDR64 | NAGPA | ENSP00000355510 | ENSP00000310998 | WD repeat domain 64. | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Catalyzes the second step in the formation of the mannose 6- phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. | 0.578 |