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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPR137BIntegral membrane protein GPR137B; G protein-coupled receptor 137B; Belongs to the GPR137 family (399 aa)    
Predicted Functional Partners:
C7orf25
UPF0415 protein C7orf25; Chromosome 7 open reading frame 25; Belongs to the UPF0415 family
      
 0.734
GPR107
Protein GPR107; Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins; Belongs to the LU7TM family
      
 0.606
GPR108
G protein-coupled receptor 108; 7TM orphan receptors
      
 0.571
C4orf48
Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48
      
 0.566
RFTN2
Raftlin-2; Raftlin family member 2; Belongs to the raftlin family
      
 0.539
SRRD
SRR1 domain containing; SRR1-like protein; May be involved in a circadian clock input pathway
      
 0.532
TMEM181
Transmembrane protein 181; Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication
      
 0.515
GPR155
Integral membrane protein GPR155; G protein-coupled receptor 155
      
 0.511
GPR114
Adhesion G-protein coupled receptor G5; Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide- binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking)
      
 0.508
TMEM185A
Transmembrane protein 185A; Belongs to the TMEM185 family
   
  
 0.508
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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