node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBOX1 | TRAT1 | ENSP00000263182 | ENSP00000295756 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family. | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | 0.980 |
BBOX1 | TRIM17 | ENSP00000263182 | ENSP00000355658 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family. | E3 ubiquitin-protein ligase TRIM17; May function as a ubiquitin E3 ligase. Belongs to the TRIM/RBCC family. | 0.977 |
BBOX1 | TRIM67 | ENSP00000263182 | ENSP00000355613 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family. | Tripartite motif containing 67; Belongs to the TRIM/RBCC family. | 0.755 |
DCC | TRIM67 | ENSP00000389140 | ENSP00000355613 | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. | Tripartite motif containing 67; Belongs to the TRIM/RBCC family. | 0.603 |
KIF1A | TRIM67 | ENSP00000438388 | ENSP00000355613 | Kinesin-like protein KIF1A; Motor for anterograde axonal transport of synaptic vesicle precursors. Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium- dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily. | Tripartite motif containing 67; Belongs to the TRIM/RBCC family. | 0.486 |
KIF1A | UNC13A | ENSP00000438388 | ENSP00000429562 | Kinesin-like protein KIF1A; Motor for anterograde axonal transport of synaptic vesicle precursors. Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium- dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily. | Protein unc-13 homolog A; Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA- mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). A [...] | 0.430 |
MYO16 | TRIM67 | ENSP00000401633 | ENSP00000355613 | Unconventional myosin-XVI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity); In the N-terminal section; belongs to the TRAFAC class myosin-kinesin [...] | Tripartite motif containing 67; Belongs to the TRIM/RBCC family. | 0.500 |
SIPA1L1 | TRIM67 | ENSP00000450832 | ENSP00000355613 | Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). | Tripartite motif containing 67; Belongs to the TRIM/RBCC family. | 0.509 |
SNAP47 | TRIM67 | ENSP00000314157 | ENSP00000355613 | Synaptosomal-associated protein 47; Plays a role in intracellular membrane fusion. | Tripartite motif containing 67; Belongs to the TRIM/RBCC family. | 0.529 |
TMEM247 | TRIM67 | ENSP00000388684 | ENSP00000355613 | Transmembrane protein 247. | Tripartite motif containing 67; Belongs to the TRIM/RBCC family. | 0.507 |
TRAT1 | BBOX1 | ENSP00000295756 | ENSP00000263182 | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family. | 0.980 |
TRAT1 | TRIM17 | ENSP00000295756 | ENSP00000355658 | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | E3 ubiquitin-protein ligase TRIM17; May function as a ubiquitin E3 ligase. Belongs to the TRIM/RBCC family. | 0.924 |
TRAT1 | TRIM67 | ENSP00000295756 | ENSP00000355613 | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | Tripartite motif containing 67; Belongs to the TRIM/RBCC family. | 0.591 |
TRIM17 | BBOX1 | ENSP00000355658 | ENSP00000263182 | E3 ubiquitin-protein ligase TRIM17; May function as a ubiquitin E3 ligase. Belongs to the TRIM/RBCC family. | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family. | 0.977 |
TRIM17 | TRAT1 | ENSP00000355658 | ENSP00000295756 | E3 ubiquitin-protein ligase TRIM17; May function as a ubiquitin E3 ligase. Belongs to the TRIM/RBCC family. | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | 0.924 |
TRIM17 | TRIM67 | ENSP00000355658 | ENSP00000355613 | E3 ubiquitin-protein ligase TRIM17; May function as a ubiquitin E3 ligase. Belongs to the TRIM/RBCC family. | Tripartite motif containing 67; Belongs to the TRIM/RBCC family. | 0.765 |
TRIM67 | BBOX1 | ENSP00000355613 | ENSP00000263182 | Tripartite motif containing 67; Belongs to the TRIM/RBCC family. | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family. | 0.755 |
TRIM67 | DCC | ENSP00000355613 | ENSP00000389140 | Tripartite motif containing 67; Belongs to the TRIM/RBCC family. | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. | 0.603 |
TRIM67 | KIF1A | ENSP00000355613 | ENSP00000438388 | Tripartite motif containing 67; Belongs to the TRIM/RBCC family. | Kinesin-like protein KIF1A; Motor for anterograde axonal transport of synaptic vesicle precursors. Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium- dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily. | 0.486 |
TRIM67 | MYO16 | ENSP00000355613 | ENSP00000401633 | Tripartite motif containing 67; Belongs to the TRIM/RBCC family. | Unconventional myosin-XVI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity); In the N-terminal section; belongs to the TRAFAC class myosin-kinesin [...] | 0.500 |