FAM72A protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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co-expression

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gene neighborhood

gene co-occurrence

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP11A	ARHGAP11B-2	ENSP00000355090	ENSP00000481934	Rho GTPase activating protein 11A.	Rho GTPase activating protein 11B.	0.834
ARHGAP11A	CCNA2	ENSP00000355090	ENSP00000481380	Rho GTPase activating protein 11A.	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin- dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	0.813
ARHGAP11A	CDCA8	ENSP00000355090	ENSP00000362146	Rho GTPase activating protein 11A.	Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.	0.811
ARHGAP11A	DLGAP5	ENSP00000355090	ENSP00000247191	Rho GTPase activating protein 11A.	Disks large-associated protein 5; Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.	0.858
ARHGAP11A	FAM72A	ENSP00000355090	ENSP00000356096	Rho GTPase activating protein 11A.	Protein FAM72A; May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation. Belongs to the FAM72 family.	0.465
ARHGAP11A	FAM72B	ENSP00000355090	ENSP00000358397	Rho GTPase activating protein 11A.	Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family.	0.493
ARHGAP11A	KIF2C	ENSP00000355090	ENSP00000361298	Rho GTPase activating protein 11A.	Kinesin-like protein KIF2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end- on conversion of the chromosome-microtubule attachment ; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.	0.762
ARHGAP11A	PBK	ENSP00000355090	ENSP00000428489	Rho GTPase activating protein 11A.	Lymphokine-activated killer T-cell-originated protein kinase; Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin- induced DNA damage; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.	0.719
ARHGAP11A	TTK	ENSP00000355090	ENSP00000358813	Rho GTPase activating protein 11A.	Dual specificity protein kinase TTK; Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.	0.847
ARHGAP11B-2	ARHGAP11A	ENSP00000481934	ENSP00000355090	Rho GTPase activating protein 11B.	Rho GTPase activating protein 11A.	0.834
ARHGAP11B-2	CCNA2	ENSP00000481934	ENSP00000481380	Rho GTPase activating protein 11B.	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin- dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	0.696
ARHGAP11B-2	CDCA8	ENSP00000481934	ENSP00000362146	Rho GTPase activating protein 11B.	Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.	0.572
ARHGAP11B-2	DLGAP5	ENSP00000481934	ENSP00000247191	Rho GTPase activating protein 11B.	Disks large-associated protein 5; Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.	0.620
ARHGAP11B-2	FAM72A	ENSP00000481934	ENSP00000356096	Rho GTPase activating protein 11B.	Protein FAM72A; May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation. Belongs to the FAM72 family.	0.456
ARHGAP11B-2	FAM72B	ENSP00000481934	ENSP00000358397	Rho GTPase activating protein 11B.	Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family.	0.612
ARHGAP11B-2	KIF2C	ENSP00000481934	ENSP00000361298	Rho GTPase activating protein 11B.	Kinesin-like protein KIF2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end- on conversion of the chromosome-microtubule attachment ; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.	0.572
ARHGAP11B-2	PBK	ENSP00000481934	ENSP00000428489	Rho GTPase activating protein 11B.	Lymphokine-activated killer T-cell-originated protein kinase; Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin- induced DNA damage; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.	0.518
ARHGAP11B-2	TTK	ENSP00000481934	ENSP00000358813	Rho GTPase activating protein 11B.	Dual specificity protein kinase TTK; Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.	0.686
CCNA2	ARHGAP11A	ENSP00000481380	ENSP00000355090	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin- dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Rho GTPase activating protein 11A.	0.813
CCNA2	ARHGAP11B-2	ENSP00000481380	ENSP00000481934	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin- dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Rho GTPase activating protein 11B.	0.696