STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHCBP1LTesticular spindle-associated protein SHCBP1L; Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells. (653 aa)    
Predicted Functional Partners:
CABS1
Calcium-binding and spermatid-specific protein 1; Calcium binding protein, spermatid associated 1.
   
  
 0.655
NCAPG
Condensin complex subunit 3; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
   
  
 0.613
SPATA3
Spermatogenesis-associated protein 3; Spermatogenesis associated 3.
   
  
 0.544
TMCO5A
Transmembrane and coiled-coil domains 5A; Belongs to the TMCO5 family.
   
  
 0.499
TMCO2
Transmembrane and coiled-coil domains 2.
   
  
 0.498
HSPA2
Heat shock-related 70 kDa protein 2; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis [...]
      
 0.495
PDCL2
Phosducin-like protein 2; May play a role in germ cell maturation; Belongs to the phosducin family.
   
  
 0.484
CCDC54
Coiled-coil domain containing 54.
   
  
 0.464
CCDC187
Coiled-coil domain containing 187.
   
  
 0.457
C12orf50
Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.
   
  
 0.455
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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