STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KIAA1614Uncharacterized protein KIAA1614; KIAA1614 (1190 aa)    
Predicted Functional Partners:
PRKCI
Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process a [...]
   
 
 0.752
PRKCZ
Protein kinase C zeta type; Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Requ [...]
   
 
 0.752
KIAA2012
Uncharacterized protein KIAA2012
      
 0.652
TPBGL
Trophoblast glycoprotein like
      
 0.642
RBBP8NL
RBBP8 N-terminal-like protein; RBBP8 N-terminal like
      
 0.578
FAM217B
Protein FAM217B; Family with sequence similarity 217 member B; Belongs to the FAM217 family
      
 0.569
FAM186A
Protein FAM186A; Family with sequence similarity 186 member A; Belongs to the FAM186 family
      
 0.553
C21orf58
Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58
      
 0.552
EXOC3L4
Exocyst complex component 3 like 4; Belongs to the SEC6 family
      
 0.533
EFCAB5
EF-hand calcium-binding domain-containing protein 5; EF-hand calcium binding domain 5
      
 0.529
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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