C1orf105 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf105	C20orf144	ENSP00000356700	ENSP00000364370	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	Uncharacterized protein C20orf144; Chromosome 20 open reading frame 144.	0.442
C1orf105	C2orf92	ENSP00000356700	ENSP00000490587	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	Uncharacterized protein C2orf92; Chromosome 2 open reading frame 92.	0.442
C1orf105	FBXO7	ENSP00000356700	ENSP00000266087	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	F-box only protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.	0.457
C1orf105	GOLGA8S	ENSP00000356700	ENSP00000455298	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	Golgin A8 family member S; Belongs to the GOLGA8 family.	0.570
C1orf105	HBP1	ENSP00000356700	ENSP00000222574	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	HMG box-containing protein 1; Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'- TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.	0.463
C1orf105	LIMD1	ENSP00000356700	ENSP00000273317	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	LIM domain-containing protein 1; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts [...]	0.678
C1orf105	MTIF2	ENSP00000356700	ENSP00000263629	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	Translation initiation factor IF-2, mitochondrial; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.	0.476
C1orf105	NAA50	ENSP00000356700	ENSP00000240922	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. [...]	0.476
C1orf105	PIGC	ENSP00000356700	ENSP00000356702	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	Phosphatidylinositol N-acetylglucosaminyltransferase subunit C; Involved in GPI anchor biosynthesis. Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis (ECO:0000269\|. Belongs to the PIGC family.	0.562
C1orf105	PPIAL4F	ENSP00000356700	ENSP00000485638	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	Peptidylprolyl isomerase A like 4F.	0.485
C20orf144	C1orf105	ENSP00000364370	ENSP00000356700	Uncharacterized protein C20orf144; Chromosome 20 open reading frame 144.	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	0.442
C2orf92	C1orf105	ENSP00000490587	ENSP00000356700	Uncharacterized protein C2orf92; Chromosome 2 open reading frame 92.	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	0.442
FBXO7	C1orf105	ENSP00000266087	ENSP00000356700	F-box only protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	0.457
GOLGA8S	C1orf105	ENSP00000455298	ENSP00000356700	Golgin A8 family member S; Belongs to the GOLGA8 family.	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	0.570
GOLGA8S	PPIAL4F	ENSP00000455298	ENSP00000485638	Golgin A8 family member S; Belongs to the GOLGA8 family.	Peptidylprolyl isomerase A like 4F.	0.716
HBP1	C1orf105	ENSP00000222574	ENSP00000356700	HMG box-containing protein 1; Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'- TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	0.463
LIMD1	C1orf105	ENSP00000273317	ENSP00000356700	LIM domain-containing protein 1; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts [...]	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	0.678
MTIF2	C1orf105	ENSP00000263629	ENSP00000356700	Translation initiation factor IF-2, mitochondrial; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	0.476
MTIF2	NAA50	ENSP00000263629	ENSP00000240922	Translation initiation factor IF-2, mitochondrial; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.	N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. [...]	0.452
NAA50	C1orf105	ENSP00000240922	ENSP00000356700	N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. [...]	Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.	0.476