node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFNA1 | SLC50A1 | ENSP00000357392 | ENSP00000357389 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Sugar transporter SWEET1; Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. | 0.504 |
FAM189B | KRTCAP2 | ENSP00000354958 | ENSP00000295682 | Protein FAM189B; Family with sequence similarity 189 member B. | Keratinocyte-associated protein 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits [...] | 0.413 |
FAM189B | SLC50A1 | ENSP00000354958 | ENSP00000357389 | Protein FAM189B; Family with sequence similarity 189 member B. | Sugar transporter SWEET1; Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. | 0.428 |
KRTCAP2 | FAM189B | ENSP00000295682 | ENSP00000354958 | Keratinocyte-associated protein 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits [...] | Protein FAM189B; Family with sequence similarity 189 member B. | 0.413 |
KRTCAP2 | SLC50A1 | ENSP00000295682 | ENSP00000357389 | Keratinocyte-associated protein 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits [...] | Sugar transporter SWEET1; Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. | 0.424 |
RAG1 | RPS25 | ENSP00000299440 | ENSP00000435096 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] | Ribosomal protein S25. | 0.412 |
RAG1 | SLC50A1 | ENSP00000299440 | ENSP00000357389 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] | Sugar transporter SWEET1; Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. | 0.683 |
RPS25 | RAG1 | ENSP00000435096 | ENSP00000299440 | Ribosomal protein S25. | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] | 0.412 |
RPS25 | RPS5 | ENSP00000435096 | ENSP00000472985 | Ribosomal protein S25. | 40S ribosomal protein S5, N-terminally processed; Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. | 0.999 |
RPS25 | SLC50A1 | ENSP00000435096 | ENSP00000357389 | Ribosomal protein S25. | Sugar transporter SWEET1; Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. | 0.451 |
RPS5 | RPS25 | ENSP00000472985 | ENSP00000435096 | 40S ribosomal protein S5, N-terminally processed; Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. | Ribosomal protein S25. | 0.999 |
RPS5 | SLC50A1 | ENSP00000472985 | ENSP00000357389 | 40S ribosomal protein S5, N-terminally processed; Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. | Sugar transporter SWEET1; Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. | 0.491 |
SHC2 | SLC50A1 | ENSP00000264554 | ENSP00000357389 | SHC-transforming protein 2; Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity). | Sugar transporter SWEET1; Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. | 0.698 |
SLC2A12 | SLC2A6 | ENSP00000275230 | ENSP00000360966 | Solute carrier family 2, facilitated glucose transporter member 12; Insulin-independent facilitative glucose transporter. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. | Solute carrier family 2, facilitated glucose transporter member 6; Probable sugar transporter that acts as a regulator of glycolysis in macrophages (Probable). Does not transport glucose. | 0.417 |
SLC2A12 | SLC50A1 | ENSP00000275230 | ENSP00000357389 | Solute carrier family 2, facilitated glucose transporter member 12; Insulin-independent facilitative glucose transporter. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. | Sugar transporter SWEET1; Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. | 0.447 |
SLC2A13 | SLC50A1 | ENSP00000280871 | ENSP00000357389 | Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Sugar transporter SWEET1; Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. | 0.449 |
SLC2A6 | SLC2A12 | ENSP00000360966 | ENSP00000275230 | Solute carrier family 2, facilitated glucose transporter member 6; Probable sugar transporter that acts as a regulator of glycolysis in macrophages (Probable). Does not transport glucose. | Solute carrier family 2, facilitated glucose transporter member 12; Insulin-independent facilitative glucose transporter. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. | 0.417 |
SLC2A6 | SLC50A1 | ENSP00000360966 | ENSP00000357389 | Solute carrier family 2, facilitated glucose transporter member 6; Probable sugar transporter that acts as a regulator of glycolysis in macrophages (Probable). Does not transport glucose. | Sugar transporter SWEET1; Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. | 0.452 |
SLC50A1 | EFNA1 | ENSP00000357389 | ENSP00000357392 | Sugar transporter SWEET1; Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | 0.504 |
SLC50A1 | FAM189B | ENSP00000357389 | ENSP00000354958 | Sugar transporter SWEET1; Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1. | Protein FAM189B; Family with sequence similarity 189 member B. | 0.428 |