CFAP46 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC105	CFAP43	ENSP00000292574	ENSP00000349568	Coiled-coil domain containing 105.	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	0.887
CCDC105	CFAP46	ENSP00000292574	ENSP00000357575	Coiled-coil domain containing 105.	Cilia- and flagella-associated protein 46; As part of the central apparatus of the cilium axoneme plays a role in cilium movement.	0.626
CCDC105	DNAH1	ENSP00000292574	ENSP00000401514	Coiled-coil domain containing 105.	Dynein heavy chain 1, axonemal; Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme ; Belongs to the dynein heavy chain family.	0.706
CCDC105	DNAH10	ENSP00000292574	ENSP00000489675	Coiled-coil domain containing 105.	Dynein heavy chain 10, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain.	0.843
CCDC105	DNAH3	ENSP00000292574	ENSP00000261383	Coiled-coil domain containing 105.	Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family.	0.827
CCDC105	EFHB	ENSP00000292574	ENSP00000295824	Coiled-coil domain containing 105.	EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.	0.986
CCDC105	EFHC1	ENSP00000292574	ENSP00000360107	Coiled-coil domain containing 105.	EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death.	0.948
CFAP43	CCDC105	ENSP00000349568	ENSP00000292574	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Coiled-coil domain containing 105.	0.887
CFAP43	CFAP46	ENSP00000349568	ENSP00000357575	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Cilia- and flagella-associated protein 46; As part of the central apparatus of the cilium axoneme plays a role in cilium movement.	0.690
CFAP43	CFAP54	ENSP00000349568	ENSP00000431759	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella.	0.674
CFAP43	DNAH1	ENSP00000349568	ENSP00000401514	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Dynein heavy chain 1, axonemal; Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme ; Belongs to the dynein heavy chain family.	0.993
CFAP43	DNAH10	ENSP00000349568	ENSP00000489675	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Dynein heavy chain 10, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain.	0.964
CFAP43	DNAH3	ENSP00000349568	ENSP00000261383	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family.	0.975
CFAP43	EFHB	ENSP00000349568	ENSP00000295824	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus.	0.994
CFAP43	EFHC1	ENSP00000349568	ENSP00000360107	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death.	0.973
CFAP43	SPEF2	ENSP00000349568	ENSP00000348314	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation.	0.806
CFAP46	CCDC105	ENSP00000357575	ENSP00000292574	Cilia- and flagella-associated protein 46; As part of the central apparatus of the cilium axoneme plays a role in cilium movement.	Coiled-coil domain containing 105.	0.626
CFAP46	CFAP43	ENSP00000357575	ENSP00000349568	Cilia- and flagella-associated protein 46; As part of the central apparatus of the cilium axoneme plays a role in cilium movement.	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	0.690
CFAP46	CFAP54	ENSP00000357575	ENSP00000431759	Cilia- and flagella-associated protein 46; As part of the central apparatus of the cilium axoneme plays a role in cilium movement.	Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella.	0.631
CFAP46	DNAH1	ENSP00000357575	ENSP00000401514	Cilia- and flagella-associated protein 46; As part of the central apparatus of the cilium axoneme plays a role in cilium movement.	Dynein heavy chain 1, axonemal; Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme ; Belongs to the dynein heavy chain family.	0.646