| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1orf109 | CALHM5 | ENSP00000350704 | ENSP00000357588 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition. | Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family. | 0.510 |
| C1orf109 | CWC25 | ENSP00000350704 | ENSP00000478070 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition. | Pre-mRNA-splicing factor CWC25 homolog; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the CWC25 family. | 0.802 |
| C1orf109 | FBXO47 | ENSP00000350704 | ENSP00000367319 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition. | F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. | 0.723 |
| C1orf109 | LINGO3 | ENSP00000350704 | ENSP00000467753 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition. | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3. | 0.738 |
| C1orf109 | MOCS3 | ENSP00000350704 | ENSP00000244051 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition. | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.743 |
| C1orf109 | RUBCNL | ENSP00000350704 | ENSP00000396935 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition. | Protein associated with UVRAG as autophagy enhancer; Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex. Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes. Binds phosphoinositides phosphatidy [...] | 0.802 |
| CALHM5 | C1orf109 | ENSP00000357588 | ENSP00000350704 | Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family. | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition. | 0.510 |
| CALHM5 | CRACR2A | ENSP00000357588 | ENSP00000409382 | Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family. | EF-hand calcium-binding domain-containing protein 4B; Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from OR [...] | 0.476 |
| CALHM5 | CWC25 | ENSP00000357588 | ENSP00000478070 | Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family. | Pre-mRNA-splicing factor CWC25 homolog; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the CWC25 family. | 0.474 |
| CALHM5 | ERC2 | ENSP00000357588 | ENSP00000288221 | Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family. | ERC protein 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ. | 0.438 |
| CALHM5 | FBXO3 | ENSP00000357588 | ENSP00000265651 | Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family. | F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. | 0.411 |
| CALHM5 | FBXO47 | ENSP00000357588 | ENSP00000367319 | Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family. | F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. | 0.445 |
| CALHM5 | LINGO3 | ENSP00000357588 | ENSP00000467753 | Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family. | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3. | 0.449 |
| CALHM5 | MOCS3 | ENSP00000357588 | ENSP00000244051 | Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family. | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.424 |
| CALHM5 | RTL6 | ENSP00000357588 | ENSP00000340434 | Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family. | Retrotransposon Gag like 6. | 0.530 |
| CALHM5 | RUBCNL | ENSP00000357588 | ENSP00000396935 | Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family. | Protein associated with UVRAG as autophagy enhancer; Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex. Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes. Binds phosphoinositides phosphatidy [...] | 0.479 |
| CRACR2A | CALHM5 | ENSP00000409382 | ENSP00000357588 | EF-hand calcium-binding domain-containing protein 4B; Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from OR [...] | Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family. | 0.476 |
| CRACR2A | RTL6 | ENSP00000409382 | ENSP00000340434 | EF-hand calcium-binding domain-containing protein 4B; Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from OR [...] | Retrotransposon Gag like 6. | 0.454 |
| CWC25 | C1orf109 | ENSP00000478070 | ENSP00000350704 | Pre-mRNA-splicing factor CWC25 homolog; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the CWC25 family. | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition. | 0.802 |
| CWC25 | CALHM5 | ENSP00000478070 | ENSP00000357588 | Pre-mRNA-splicing factor CWC25 homolog; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the CWC25 family. | Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family. | 0.474 |
