CALHM6 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf109	CALHM6	ENSP00000350704	ENSP00000357594	Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition.	Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel.	0.510
C1orf109	CWC25	ENSP00000350704	ENSP00000478070	Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition.	Pre-mRNA-splicing factor CWC25 homolog; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the CWC25 family.	0.802
C1orf109	FBXO47	ENSP00000350704	ENSP00000367319	Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition.	F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.	0.723
C1orf109	LINGO3	ENSP00000350704	ENSP00000467753	Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition.	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3.	0.738
C1orf109	RUBCNL	ENSP00000350704	ENSP00000396935	Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition.	Protein associated with UVRAG as autophagy enhancer; Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex. Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes. Binds phosphoinositides phosphatidy [...]	0.802
CALHM6	C1orf109	ENSP00000357594	ENSP00000350704	Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel.	Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition.	0.510
CALHM6	CWC25	ENSP00000357594	ENSP00000478070	Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel.	Pre-mRNA-splicing factor CWC25 homolog; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the CWC25 family.	0.474
CALHM6	CXCL9	ENSP00000357594	ENSP00000354901	Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel.	C-X-C motif chemokine 9; Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3; Belongs to the intercrine alpha (chemokine CxC) family.	0.434
CALHM6	EPSTI1	ENSP00000357594	ENSP00000318982	Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel.	Epithelial-stromal interaction protein 1; Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity). Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages (By similarity).	0.486
CALHM6	FBXO47	ENSP00000357594	ENSP00000367319	Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel.	F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.	0.445
CALHM6	GBP1	ENSP00000357594	ENSP00000359504	Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel.	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.	0.439
CALHM6	GBP4	ENSP00000357594	ENSP00000359490	Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel.	Guanylate-binding protein 4; Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).	0.464
CALHM6	GBP5	ENSP00000357594	ENSP00000359488	Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel.	Guanylate-binding protein 5; As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP. Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.	0.676
CALHM6	LINGO3	ENSP00000357594	ENSP00000467753	Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel.	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3.	0.449
CALHM6	RUBCNL	ENSP00000357594	ENSP00000396935	Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel.	Protein associated with UVRAG as autophagy enhancer; Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex. Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes. Binds phosphoinositides phosphatidy [...]	0.479
CWC25	C1orf109	ENSP00000478070	ENSP00000350704	Pre-mRNA-splicing factor CWC25 homolog; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the CWC25 family.	Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition.	0.802
CWC25	CALHM6	ENSP00000478070	ENSP00000357594	Pre-mRNA-splicing factor CWC25 homolog; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the CWC25 family.	Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel.	0.474
CWC25	LINGO3	ENSP00000478070	ENSP00000467753	Pre-mRNA-splicing factor CWC25 homolog; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the CWC25 family.	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3.	0.645
CWC25	RUBCNL	ENSP00000478070	ENSP00000396935	Pre-mRNA-splicing factor CWC25 homolog; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the CWC25 family.	Protein associated with UVRAG as autophagy enhancer; Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex. Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes. Binds phosphoinositides phosphatidy [...]	0.802
CXCL9	CALHM6	ENSP00000354901	ENSP00000357594	C-X-C motif chemokine 9; Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3; Belongs to the intercrine alpha (chemokine CxC) family.	Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel.	0.434