node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDSN | FLG | ENSP00000365465 | ENSP00000357789 | Corneodesmosin; Important for the epidermal barrier integrity. | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | 0.737 |
CDSN | FLG2 | ENSP00000365465 | ENSP00000373370 | Corneodesmosin; Important for the epidermal barrier integrity. | Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. In the N-terminal section; belongs to the S-100 family. | 0.790 |
CDSN | IVL | ENSP00000365465 | ENSP00000357753 | Corneodesmosin; Important for the epidermal barrier integrity. | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | 0.810 |
CDSN | KRT1 | ENSP00000365465 | ENSP00000252244 | Corneodesmosin; Important for the epidermal barrier integrity. | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. | 0.699 |
CDSN | KRT10 | ENSP00000365465 | ENSP00000269576 | Corneodesmosin; Important for the epidermal barrier integrity. | Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur. | 0.687 |
CDSN | LOR | ENSP00000365465 | ENSP00000357731 | Corneodesmosin; Important for the epidermal barrier integrity. | Loricrin; Major keratinocyte cell envelope protein. | 0.933 |
CDSN | SPRR1B | ENSP00000365465 | ENSP00000306461 | Corneodesmosin; Important for the epidermal barrier integrity. | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage; Belongs to the cornifin (SPRR) family. | 0.745 |
CDSN | SPRR3 | ENSP00000365465 | ENSP00000330391 | Corneodesmosin; Important for the epidermal barrier integrity. | Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes. | 0.659 |
CDSN | TCHH | ENSP00000365465 | ENSP00000480484 | Corneodesmosin; Important for the epidermal barrier integrity. | Trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. | 0.616 |
CDSN | TGM1 | ENSP00000365465 | ENSP00000206765 | Corneodesmosin; Important for the epidermal barrier integrity. | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation ; Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.800 |
FLG | CDSN | ENSP00000357789 | ENSP00000365465 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.737 |
FLG | FLG2 | ENSP00000357789 | ENSP00000373370 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. In the N-terminal section; belongs to the S-100 family. | 0.832 |
FLG | IVL | ENSP00000357789 | ENSP00000357753 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family. | 0.997 |
FLG | KRT1 | ENSP00000357789 | ENSP00000252244 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. | 0.953 |
FLG | KRT10 | ENSP00000357789 | ENSP00000269576 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur. | 0.932 |
FLG | LOR | ENSP00000357789 | ENSP00000357731 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Loricrin; Major keratinocyte cell envelope protein. | 0.998 |
FLG | SPRR1B | ENSP00000357789 | ENSP00000306461 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage; Belongs to the cornifin (SPRR) family. | 0.820 |
FLG | SPRR3 | ENSP00000357789 | ENSP00000330391 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes. | 0.744 |
FLG | TCHH | ENSP00000357789 | ENSP00000480484 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. | 0.831 |
FLG | TGM1 | ENSP00000357789 | ENSP00000206765 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation ; Belongs to the transglutaminase superfamily. Transglutaminase family. | 0.907 |