node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRNN | KPRP | ENSP00000271835 | ENSP00000475216 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Keratinocyte proline rich protein. | 0.560 |
CRNN | S100A11 | ENSP00000271835 | ENSP00000271638 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Protein S100-A11, N-terminally processed; Facilitates the differentiation and the cornification of keratinocytes; Belongs to the S-100 family. | 0.412 |
CRNN | TCHHL1 | ENSP00000271835 | ENSP00000357796 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Trichohyalin-like protein 1; Trichohyalin like 1; Belongs to the S-100 family. | 0.601 |
KPRP | CRNN | ENSP00000475216 | ENSP00000271835 | Keratinocyte proline rich protein. | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | 0.560 |
KPRP | LCE3C | ENSP00000475216 | ENSP00000334644 | Keratinocyte proline rich protein. | Late cornified envelope protein 3C; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. | 0.430 |
KPRP | LELP1 | ENSP00000475216 | ENSP00000357736 | Keratinocyte proline rich protein. | Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family. | 0.645 |
KPRP | S100A11 | ENSP00000475216 | ENSP00000271638 | Keratinocyte proline rich protein. | Protein S100-A11, N-terminally processed; Facilitates the differentiation and the cornification of keratinocytes; Belongs to the S-100 family. | 0.470 |
KPRP | S100A2 | ENSP00000475216 | ENSP00000499289 | Keratinocyte proline rich protein. | Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth. | 0.487 |
KPRP | S100A3 | ENSP00000475216 | ENSP00000357702 | Keratinocyte proline rich protein. | Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation. | 0.503 |
KPRP | SPRR4 | ENSP00000475216 | ENSP00000332163 | Keratinocyte proline rich protein. | Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification; Belongs to the cornifin (SPRR) family. | 0.694 |
KPRP | TCHHL1 | ENSP00000475216 | ENSP00000357796 | Keratinocyte proline rich protein. | Trichohyalin-like protein 1; Trichohyalin like 1; Belongs to the S-100 family. | 0.522 |
LCE3C | KPRP | ENSP00000334644 | ENSP00000475216 | Late cornified envelope protein 3C; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. | Keratinocyte proline rich protein. | 0.430 |
LCE3C | LELP1 | ENSP00000334644 | ENSP00000357736 | Late cornified envelope protein 3C; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. | Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family. | 0.671 |
LCE3C | SPRR4 | ENSP00000334644 | ENSP00000332163 | Late cornified envelope protein 3C; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. | Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification; Belongs to the cornifin (SPRR) family. | 0.567 |
LCE3C | TCHHL1 | ENSP00000334644 | ENSP00000357796 | Late cornified envelope protein 3C; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. | Trichohyalin-like protein 1; Trichohyalin like 1; Belongs to the S-100 family. | 0.501 |
LELP1 | KPRP | ENSP00000357736 | ENSP00000475216 | Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family. | Keratinocyte proline rich protein. | 0.645 |
LELP1 | LCE3C | ENSP00000357736 | ENSP00000334644 | Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family. | Late cornified envelope protein 3C; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. | 0.671 |
LELP1 | S100A11 | ENSP00000357736 | ENSP00000271638 | Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family. | Protein S100-A11, N-terminally processed; Facilitates the differentiation and the cornification of keratinocytes; Belongs to the S-100 family. | 0.465 |
LELP1 | S100A2 | ENSP00000357736 | ENSP00000499289 | Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family. | Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth. | 0.512 |
LELP1 | S100A3 | ENSP00000357736 | ENSP00000357702 | Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family. | Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation. | 0.470 |