node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD40 | C7orf25 | ENSP00000285243 | ENSP00000413029 | Ankyrin repeat domain 40. | UPF0415 protein C7orf25; Chromosome 7 open reading frame 25; Belongs to the UPF0415 family. | 0.400 |
ANKRD40 | FAM204A | ENSP00000285243 | ENSP00000358183 | Ankyrin repeat domain 40. | Protein FAM204A; Family with sequence similarity 204 member A. | 0.446 |
C7orf25 | ANKRD40 | ENSP00000413029 | ENSP00000285243 | UPF0415 protein C7orf25; Chromosome 7 open reading frame 25; Belongs to the UPF0415 family. | Ankyrin repeat domain 40. | 0.400 |
C7orf25 | FAM204A | ENSP00000413029 | ENSP00000358183 | UPF0415 protein C7orf25; Chromosome 7 open reading frame 25; Belongs to the UPF0415 family. | Protein FAM204A; Family with sequence similarity 204 member A. | 0.478 |
CHCHD3 | FAM204A | ENSP00000389297 | ENSP00000358183 | MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. | Protein FAM204A; Family with sequence similarity 204 member A. | 0.460 |
FAM133B | FAM204A | ENSP00000398401 | ENSP00000358183 | Protein FAM133B; Family with sequence similarity 133 member B. | Protein FAM204A; Family with sequence similarity 204 member A. | 0.496 |
FAM177A1 | FAM204A | ENSP00000280987 | ENSP00000358183 | Protein FAM177A1; Family with sequence similarity 177 member A1. | Protein FAM204A; Family with sequence similarity 204 member A. | 0.473 |
FAM204A | ANKRD40 | ENSP00000358183 | ENSP00000285243 | Protein FAM204A; Family with sequence similarity 204 member A. | Ankyrin repeat domain 40. | 0.446 |
FAM204A | C7orf25 | ENSP00000358183 | ENSP00000413029 | Protein FAM204A; Family with sequence similarity 204 member A. | UPF0415 protein C7orf25; Chromosome 7 open reading frame 25; Belongs to the UPF0415 family. | 0.478 |
FAM204A | CHCHD3 | ENSP00000358183 | ENSP00000389297 | Protein FAM204A; Family with sequence similarity 204 member A. | MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. | 0.460 |
FAM204A | FAM133B | ENSP00000358183 | ENSP00000398401 | Protein FAM204A; Family with sequence similarity 204 member A. | Protein FAM133B; Family with sequence similarity 133 member B. | 0.496 |
FAM204A | FAM177A1 | ENSP00000358183 | ENSP00000280987 | Protein FAM204A; Family with sequence similarity 204 member A. | Protein FAM177A1; Family with sequence similarity 177 member A1. | 0.473 |
FAM204A | HSF2 | ENSP00000358183 | ENSP00000357440 | Protein FAM204A; Family with sequence similarity 204 member A. | Heat shock factor protein 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. | 0.542 |
FAM204A | MFAP3L | ENSP00000358183 | ENSP00000354583 | Protein FAM204A; Family with sequence similarity 204 member A. | Microfibrillar-associated protein 3-like; May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis. | 0.527 |
FAM204A | RAB11FIP2 | ENSP00000358183 | ENSP00000358200 | Protein FAM204A; Family with sequence similarity 204 member A. | Rab11 family-interacting protein 2; A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator [...] | 0.491 |
FAM204A | SLU7 | ENSP00000358183 | ENSP00000297151 | Protein FAM204A; Family with sequence similarity 204 member A. | Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. | 0.485 |
FAM204A | TMEM184C | ENSP00000358183 | ENSP00000296582 | Protein FAM204A; Family with sequence similarity 204 member A. | Transmembrane protein 184C; Possible tumor suppressor which may play a role in cell growth; Belongs to the TMEM184 family. | 0.626 |
HSF2 | FAM204A | ENSP00000357440 | ENSP00000358183 | Heat shock factor protein 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. | Protein FAM204A; Family with sequence similarity 204 member A. | 0.542 |
HSF2 | RAB11FIP2 | ENSP00000357440 | ENSP00000358200 | Heat shock factor protein 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. | Rab11 family-interacting protein 2; A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator [...] | 0.417 |
HSF2 | TMEM184C | ENSP00000357440 | ENSP00000296582 | Heat shock factor protein 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. | Transmembrane protein 184C; Possible tumor suppressor which may play a role in cell growth; Belongs to the TMEM184 family. | 0.515 |