STRINGSTRING
VAX1 protein (human) - STRING interaction network
"VAX1" - Ventral anterior homeobox 1 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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VAX1Ventral anterior homeobox 1; Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk (By similarity) (334 aa)    
Predicted Functional Partners:
ZNF462
Zinc finger protein 462; May be involved in transcriptional regulation (2506 aa)
     
 
  0.869
ASXL2
Additional sex combs like 2 (Drosophila); Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome prol [...] (1435 aa)
           
  0.789
SIX3
SIX homeobox 3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required [...] (332 aa)
       
 
  0.484
PAX2
Paired box 2; Transcription factor that may have a role in kidney cell differentiation (PubMed-24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS (417 aa)
     
   
  0.405
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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