node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARGLU1 | LUC7L3 | ENSP00000383059 | ENSP00000376919 | Arginine and glutamate-rich protein 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | 0.728 |
ARGLU1 | NKTR | ENSP00000383059 | ENSP00000232978 | Arginine and glutamate-rich protein 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. | NK-tumor recognition protein; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumor-recognition complex involved in the function of NK cells. | 0.411 |
ARGLU1 | PNISR | ENSP00000383059 | ENSP00000496842 | Arginine and glutamate-rich protein 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | 0.779 |
ARGLU1 | PNN | ENSP00000383059 | ENSP00000216832 | Arginine and glutamate-rich protein 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. | Pinin; Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation [...] | 0.594 |
ARGLU1 | RBM39 | ENSP00000383059 | ENSP00000253363 | Arginine and glutamate-rich protein 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. | 0.493 |
ARGLU1 | SRSF11 | ENSP00000383059 | ENSP00000359988 | Arginine and glutamate-rich protein 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. | Serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing. | 0.782 |
ARGLU1 | U2AF2 | ENSP00000383059 | ENSP00000307863 | Arginine and glutamate-rich protein 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. | Splicing factor U2AF 65 kDa subunit; Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucl [...] | 0.688 |
LUC7L3 | ARGLU1 | ENSP00000376919 | ENSP00000383059 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Arginine and glutamate-rich protein 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. | 0.728 |
LUC7L3 | NKTR | ENSP00000376919 | ENSP00000232978 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | NK-tumor recognition protein; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumor-recognition complex involved in the function of NK cells. | 0.580 |
LUC7L3 | PNISR | ENSP00000376919 | ENSP00000496842 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | 0.999 |
LUC7L3 | PNN | ENSP00000376919 | ENSP00000216832 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Pinin; Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation [...] | 0.796 |
LUC7L3 | PRPF39 | ENSP00000376919 | ENSP00000348010 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing. | 0.921 |
LUC7L3 | RBM39 | ENSP00000376919 | ENSP00000253363 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. | 0.957 |
LUC7L3 | SRSF11 | ENSP00000376919 | ENSP00000359988 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing. | 0.915 |
LUC7L3 | SRSF2 | ENSP00000376919 | ENSP00000376276 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5 [...] | 0.608 |
LUC7L3 | U2AF2 | ENSP00000376919 | ENSP00000307863 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | Splicing factor U2AF 65 kDa subunit; Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucl [...] | 0.820 |
NKTR | ARGLU1 | ENSP00000232978 | ENSP00000383059 | NK-tumor recognition protein; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumor-recognition complex involved in the function of NK cells. | Arginine and glutamate-rich protein 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1. | 0.411 |
NKTR | LUC7L3 | ENSP00000232978 | ENSP00000376919 | NK-tumor recognition protein; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumor-recognition complex involved in the function of NK cells. | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. | 0.580 |
NKTR | PNISR | ENSP00000232978 | ENSP00000496842 | NK-tumor recognition protein; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumor-recognition complex involved in the function of NK cells. | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family. | 0.875 |
NKTR | PNN | ENSP00000232978 | ENSP00000216832 | NK-tumor recognition protein; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumor-recognition complex involved in the function of NK cells. | Pinin; Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation [...] | 0.518 |