KLHL32 protein (human) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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co-expression

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gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK4	KLHL32	ENSP00000257904	ENSP00000358265	Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...]	Kelch-like protein 32; Kelch like family member 32.	0.457
ERICH3	KLHL32	ENSP00000322609	ENSP00000358265	Glutamate-rich protein 3; Glutamate rich 3.	Kelch-like protein 32; Kelch like family member 32.	0.488
FBXL4	KLHL32	ENSP00000358247	ENSP00000358265	F-box and leucine rich repeat protein 4.	Kelch-like protein 32; Kelch like family member 32.	0.458
FBXL4	MMS22L	ENSP00000358247	ENSP00000275053	F-box and leucine rich repeat protein 4.	Protein MMS22-like; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double- strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA.	0.466
GPR22	GPR63	ENSP00000302676	ENSP00000229955	G-protein coupled receptor 22; Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway. May be involved in ciliogenesis (By similarity).	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	0.554
GPR22	KLHL32	ENSP00000302676	ENSP00000358265	G-protein coupled receptor 22; Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway. May be involved in ciliogenesis (By similarity).	Kelch-like protein 32; Kelch like family member 32.	0.482
GPR63	GPR22	ENSP00000229955	ENSP00000302676	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	G-protein coupled receptor 22; Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway. May be involved in ciliogenesis (By similarity).	0.554
GPR63	KLHL32	ENSP00000229955	ENSP00000358265	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	Kelch-like protein 32; Kelch like family member 32.	0.668
GPR63	MANEA	ENSP00000229955	ENSP00000351669	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha.	0.424
GPR63	MMS22L	ENSP00000229955	ENSP00000275053	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	Protein MMS22-like; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double- strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA.	0.503
GPR63	NDUFAF4	ENSP00000229955	ENSP00000358272	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion.	0.518
KLHL32	CDK4	ENSP00000358265	ENSP00000257904	Kelch-like protein 32; Kelch like family member 32.	Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...]	0.457
KLHL32	ERICH3	ENSP00000358265	ENSP00000322609	Kelch-like protein 32; Kelch like family member 32.	Glutamate-rich protein 3; Glutamate rich 3.	0.488
KLHL32	FBXL4	ENSP00000358265	ENSP00000358247	Kelch-like protein 32; Kelch like family member 32.	F-box and leucine rich repeat protein 4.	0.458
KLHL32	GPR22	ENSP00000358265	ENSP00000302676	Kelch-like protein 32; Kelch like family member 32.	G-protein coupled receptor 22; Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway. May be involved in ciliogenesis (By similarity).	0.482
KLHL32	GPR63	ENSP00000358265	ENSP00000229955	Kelch-like protein 32; Kelch like family member 32.	Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.	0.668
KLHL32	MANEA	ENSP00000358265	ENSP00000351669	Kelch-like protein 32; Kelch like family member 32.	Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha.	0.474
KLHL32	MMS22L	ENSP00000358265	ENSP00000275053	Kelch-like protein 32; Kelch like family member 32.	Protein MMS22-like; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double- strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA.	0.643
KLHL32	NDUFAF4	ENSP00000358265	ENSP00000358272	Kelch-like protein 32; Kelch like family member 32.	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion.	0.484
KLHL32	PARVG	ENSP00000358265	ENSP00000391583	Kelch-like protein 32; Kelch like family member 32.	Gamma-parvin; Probably plays a role in the regulation of cell adhesion and cytoskeleton organization; Belongs to the parvin family.	0.464