node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC186 | NHLRC2 | ENSP00000498136 | ENSP00000358307 | Coiled-coil domain containing 186. | NHL repeat-containing protein 2; Required for normal embryonic development. | 0.605 |
CCDC186 | PLEKHS1 | ENSP00000498136 | ENSP00000358316 | Coiled-coil domain containing 186. | Pleckstrin homology domain containing S1. | 0.481 |
CCDC186 | TECTB | ENSP00000498136 | ENSP00000494896 | Coiled-coil domain containing 186. | Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.464 |
CCDC186 | VTI1A | ENSP00000498136 | ENSP00000376792 | Coiled-coil domain containing 186. | Vesicle transport through interaction with t-SNAREs homolog 1A; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular [...] | 0.462 |
DPH3 | PLEKHS1 | ENSP00000419599 | ENSP00000358316 | DPH3 homolog; Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH3 family. | Pleckstrin homology domain containing S1. | 0.466 |
LEPROTL1 | PLEKHS1 | ENSP00000428281 | ENSP00000358316 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | Pleckstrin homology domain containing S1. | 0.539 |
LEPROTL1 | TBC1D12 | ENSP00000428281 | ENSP00000225235 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | 0.615 |
LEPROTL1 | WDR74 | ENSP00000428281 | ENSP00000432119 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | WD repeat-containing protein 74; Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL. Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (By similarity). | 0.504 |
NHLRC2 | CCDC186 | ENSP00000358307 | ENSP00000498136 | NHL repeat-containing protein 2; Required for normal embryonic development. | Coiled-coil domain containing 186. | 0.605 |
NHLRC2 | PLEKHS1 | ENSP00000358307 | ENSP00000358316 | NHL repeat-containing protein 2; Required for normal embryonic development. | Pleckstrin homology domain containing S1. | 0.475 |
NHLRC2 | TECTB | ENSP00000358307 | ENSP00000494896 | NHL repeat-containing protein 2; Required for normal embryonic development. | Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.470 |
NHLRC2 | VTI1A | ENSP00000358307 | ENSP00000376792 | NHL repeat-containing protein 2; Required for normal embryonic development. | Vesicle transport through interaction with t-SNAREs homolog 1A; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular [...] | 0.445 |
PBLD | PLEKHS1 | ENSP00000351619 | ENSP00000358316 | Phenazine biosynthesis like protein domain containing. | Pleckstrin homology domain containing S1. | 0.467 |
PLEKHS1 | CCDC186 | ENSP00000358316 | ENSP00000498136 | Pleckstrin homology domain containing S1. | Coiled-coil domain containing 186. | 0.481 |
PLEKHS1 | DPH3 | ENSP00000358316 | ENSP00000419599 | Pleckstrin homology domain containing S1. | DPH3 homolog; Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH3 family. | 0.466 |
PLEKHS1 | LEPROTL1 | ENSP00000358316 | ENSP00000428281 | Pleckstrin homology domain containing S1. | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family. | 0.539 |
PLEKHS1 | NHLRC2 | ENSP00000358316 | ENSP00000358307 | Pleckstrin homology domain containing S1. | NHL repeat-containing protein 2; Required for normal embryonic development. | 0.475 |
PLEKHS1 | PBLD | ENSP00000358316 | ENSP00000351619 | Pleckstrin homology domain containing S1. | Phenazine biosynthesis like protein domain containing. | 0.467 |
PLEKHS1 | TBC1D12 | ENSP00000358316 | ENSP00000225235 | Pleckstrin homology domain containing S1. | TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth. | 0.671 |
PLEKHS1 | TECTB | ENSP00000358316 | ENSP00000494896 | Pleckstrin homology domain containing S1. | Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.460 |