node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS9 | DHRS13 | ENSP00000418735 | ENSP00000368173 | A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | 0.561 |
ADAMTS9 | PRSS35 | ENSP00000418735 | ENSP00000358714 | A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. | Serine protease 35; Belongs to the peptidase S1 family. | 0.446 |
DHRS13 | ADAMTS9 | ENSP00000368173 | ENSP00000418735 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. | 0.561 |
DHRS13 | KCNQ3 | ENSP00000368173 | ENSP00000373648 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. | 0.485 |
DHRS13 | PRSS35 | ENSP00000368173 | ENSP00000358714 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | Serine protease 35; Belongs to the peptidase S1 family. | 0.564 |
DHRS13 | RGS17 | ENSP00000368173 | ENSP00000206262 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | Regulator of G-protein signaling 17; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). | 0.508 |
KCNQ3 | DHRS13 | ENSP00000373648 | ENSP00000368173 | Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | 0.485 |
KCNQ3 | MDGA2 | ENSP00000373648 | ENSP00000405456 | Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. | MAM domain-containing glycosylphosphatidylinositol anchor protein 2; May be involved in cell-cell interactions. | 0.475 |
KCNQ3 | PRSS35 | ENSP00000373648 | ENSP00000358714 | Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. | Serine protease 35; Belongs to the peptidase S1 family. | 0.416 |
KCNQ3 | RGS17 | ENSP00000373648 | ENSP00000206262 | Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. | Regulator of G-protein signaling 17; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). | 0.425 |
MDGA2 | KCNQ3 | ENSP00000405456 | ENSP00000373648 | MAM domain-containing glycosylphosphatidylinositol anchor protein 2; May be involved in cell-cell interactions. | Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. | 0.475 |
MDGA2 | PRSS35 | ENSP00000405456 | ENSP00000358714 | MAM domain-containing glycosylphosphatidylinositol anchor protein 2; May be involved in cell-cell interactions. | Serine protease 35; Belongs to the peptidase S1 family. | 0.457 |
MDGA2 | RGS17 | ENSP00000405456 | ENSP00000206262 | MAM domain-containing glycosylphosphatidylinositol anchor protein 2; May be involved in cell-cell interactions. | Regulator of G-protein signaling 17; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). | 0.423 |
PRSS35 | ADAMTS9 | ENSP00000358714 | ENSP00000418735 | Serine protease 35; Belongs to the peptidase S1 family. | A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. | 0.446 |
PRSS35 | DHRS13 | ENSP00000358714 | ENSP00000368173 | Serine protease 35; Belongs to the peptidase S1 family. | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. | 0.564 |
PRSS35 | KCNQ3 | ENSP00000358714 | ENSP00000373648 | Serine protease 35; Belongs to the peptidase S1 family. | Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. | 0.416 |
PRSS35 | MDGA2 | ENSP00000358714 | ENSP00000405456 | Serine protease 35; Belongs to the peptidase S1 family. | MAM domain-containing glycosylphosphatidylinositol anchor protein 2; May be involved in cell-cell interactions. | 0.457 |
PRSS35 | RANBP3L | ENSP00000358714 | ENSP00000421853 | Serine protease 35; Belongs to the peptidase S1 family. | Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner. | 0.417 |
PRSS35 | RGS17 | ENSP00000358714 | ENSP00000206262 | Serine protease 35; Belongs to the peptidase S1 family. | Regulator of G-protein signaling 17; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). | 0.449 |
PRSS35 | SNAP91 | ENSP00000358714 | ENSP00000400459 | Serine protease 35; Belongs to the peptidase S1 family. | Clathrin coat assembly protein AP180; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60- 70 nm coats (By similarity); Belongs to the PICALM/SNAP91 family. | 0.451 |